Capa Capability [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Capaprovided by FlyBase
Official Full Name: Capabilityprovided by FlyBase
Primary source: FLYBASE:FBgn0039722
Locus tag: Dmel_CG15520
See related: AllianceGenome:FB:FBgn0039722
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CAP; Cap-1; Cap-2; Cap-2b; CAP-2b; Cap-3; CAP2b; CAP2b-1; CAP2B-1; CAP2b-2; CAP2B-2; CAP2b-3; CAP2B-3; CAP2B/pyrokinin; capa; CAPA; capa 2; capa-1; Capa-1; capa-2; Capa-2; capa-3; Capa-PK; CAPA-PK; CAPA-PVK-1; CAPA-PVK-2; CAPA-PVK/PK; CAP[[2b]]; CG15520; CPPB; Dmel\CG15520; Drm-CAP-1; Drm-CAP-2; Drm-CAP2b/MT; Drm-capa-1; Drm-MT; Drm-PK; Drm-PK-1; Drm-PVK; Drm-PVK-1; Drm-PVK-2; Drome-capa-1; PVK-2; pyrokinin/PBAN-like
Summary: Enables hormone activity and neuropeptide receptor binding activity. Involved in several processes, including epithelial fluid transport; neuropeptide signaling pathway; and nitric oxide-cGMP-mediated signaling. Located in extracellular space. Is expressed in Malpighian tubule; Va neurons; larval central nervous system; larval subesophageal capability neurons; and ventral group vA neuron. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 99C6-99C6; 3-99 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29912991..29914346, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (25738713..25740068, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A nutrient-responsive hormonal circuit mediates an inter-tissue program regulating metabolic homeostasis in adult Drosophila.
Title: A nutrient-responsive hormonal circuit mediates an inter-tissue program regulating metabolic homeostasis in adult Drosophila.
This study provides evidence that low (femtomolar) and high (micromolar) doses of CAPA impair and improve chill tolerance, respectively, via two different effects on Malpighian tubule ion and water transport. While low doses of CAPA are anti-diuretic, reduce tubule K(+) clearance rates and reduce chill tolerance, high doses facilitate K(+) clearance from the haemolymph and increase chill tolerance.
Title: Anti-diuretic activity of a CAPA neuropeptide can compromise Drosophila chill tolerance.
Va-A1 neurons terminally differentiate into DH31/AstA-expressing neurons (neuropeptidergic fate I) by virtue of Ubx activity, and Va-A2-A4 neurons terminally differentiate into Capa-expressing neurons
Title: Segmentally homologous neurons acquire two different terminal neuropeptidergic fates in the Drosophila nervous system.
regulation of cellular ion and water homeostasis mediated by capa peptide signaling in the insect Malpighian (renal) tubules is a key physiological mechanism during recovery from desiccation and cold stress.
Title: Insect capa neuropeptides impact desiccation and cold tolerance.
Developmental appearance of the peptidergic, Capability-expressing Va neurons
Title: Segment-specific generation of Drosophila Capability neuropeptide neurons by multi-faceted Hox cues.
99D on chromosome 3R potentially encodes GANMGLYAFPRV-amide (capa-1), ASGLVAFPRV-amide (capa-2), and TGPSASSGLWGPRL-amide (capa-3). neuroendocrine cells release capa peptides into hemolymph
Title: Two nitridergic peptides are encoded by the gene capability in Drosophila melanogaster.
cloning and expression of a receptor for capa-1 and capa-2 in Drosophila
Title: Molecular cloning and functional expression of a Drosophila receptor for the neuropeptides capa-1 and -2.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables diuretic hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables myostimulatory hormone activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables neuropeptide hormone activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables neuropeptide receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in epithelial fluid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic cation transport	TAS Traceable Author Statement more info	PubMed
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuropeptide signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nitric oxide-cGMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: capability

Names: CAP; CAP2B-like; CG15520-PA; Capa-PA; Drm-myotropin; TGPSASSGLWFGPRLamide; cardio acceleratory peptide; cardioacceleratory peptide-2b; myotropin; myotropin-CAP2b-like; periviscerokinin; pyrokinin; pyrokinin-1; pyrokinin-like