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    Rad1 Radiation insensitive 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33440, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rad1provided by FlyBase
    Official Full Name
    Radiation insensitive 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0026778
    Locus tag
    Dmel_CG3240
    See related
    AllianceGenome:FB:FBgn0026778
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3240; Dmel\CG3240; DmRad1; Dromel_CG3240_FBtr0077747_rad1_mORF; rad1; Rad1[Dm]
    Summary
    Predicted to be involved in DNA damage checkpoint signaling and DNA repair. Part of checkpoint clamp complex. Is expressed in ovary. Orthologous to human RAD1 (RAD1 checkpoint DNA exonuclease). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rad1 in Genome Data Viewer
    Location:
    23A1-23A1; 2-7 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2573436..2575052, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2573436..2575052, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 309a1 Neighboring gene Cytochrome P450 309a2 Neighboring gene SWIM domain containing Srs2 interacting protein 1 Neighboring gene insensitive Neighboring gene Early boundary activity 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Localization of the Drosophila Rad9 protein to the nuclear membrane is regulated by the C-terminal region and is affected in the meiotic checkpoint. Kadir R, et al. PLoS One, 2012. PMID 22666434, Free PMC Article
    2. p53 and cyclin G cooperate in mediating genome stability in somatic cells of Drosophila. Bayer FE, et al. Sci Rep, 2017 Dec 20. PMID 29263364, Free PMC Article
    3. An essential role for Drosophila hus1 in somatic and meiotic DNA damage responses. Abdu U, et al. J Cell Sci, 2007 Mar 15. PMID 17327271, Free PMC Article
    4. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Ashburner M, et al. Nat Genet, 2000 May. PMID 10802651, Free PMC Article
    5. The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation. Li F, et al. Nat Commun, 2021 Jun 22. PMID 34158506, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of checkpoint clamp complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of checkpoint clamp complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    radiation insensitive 1
    Names
    CG3240-PA
    Rad1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2573436..2575052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058092.4 → NP_477440.1  radiation insensitive 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477440.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQD4, Q9XYT3
      Related
      FBpp0077427
      Conserved Domains (2) summary
      cd00577
      Location:13 → 272
      PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
      pfam02144
      Location:13 → 253
      Rad1; Repair protein Rad1/Rec1/Rad17
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VQD4 Q9VQD4

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