UTS2B urotensin 2B [Homo sapiens (human)] - Gene

Summary

Official Symbol: UTS2Bprovided by HGNC
Official Full Name: urotensin 2Bprovided by HGNC
Primary source: HGNC:HGNC:30894
See related: Ensembl:ENSG00000188958 MIM:618134; AllianceGenome:HGNC:30894
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: U2B; URP; UIIB; U-IIB; UTS2D
Summary: Predicted to enable G protein-coupled receptor binding activity. Predicted to be involved in regulation of blood pressure. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jan 2025]
Expression: Low expression observed in reference dataset See more
Orthologs: mouse all
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Genomic context

Location:: 3q28

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (191267168..191346182, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (194081889..194166084, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (190984957..191048315, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

family-based analysis of association between blood pressure, glomerular filtration and genes of the urotensin-II pathway (urotensin-II, urotensin-II related peptide, urotensin-II receptor) saturated with 28 tagging single nucleotide polymorphisms
Title: Urotensin-II system in genetic control of blood pressure and renal function.
U2B'' has a relaxed specificity for its RNA targets.
Title: Human U2B″ protein binding to snRNA stemloops.
Elevated serum urotensin II is associated with chronic liver disease and portal hypertension
Title: Urotensin II: a novel vasoactive mediator linked to chronic liver disease and portal hypertension.
vascular remodelling processes in conjunction with enhanced vasoconstriction are involved in the pathogenesis of pulmonary hypertension; UII may play a novel role in the pathogenesis of this disorder
Title: Urotensin-II in the lung: a matter for vascular remodelling and pulmonary hypertension?
Urotensin II gene may contribute to the genetic susceptibility to gestational diabetes mellitus in Chinese population
Title: [Role of urotensin II gene in the genetic susceptibility to gestational diabetes mellitus in northern Chinese women].
These findings suggest that U-II plays key roles in accelerating the development of atherosclerosis, thereby leading to coronary artery disease.
Title: Human urotensin II as a link between hypertension and coronary artery disease.
URP could possibly be the endogenous and functional ligand for the human UII receptor
Title: Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH103754 (e-PCR)
- UniSTS:98079

NoName (e-PCR)
- UniSTS:483168

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in blood vessel diameter maintenance	IEA Inferred from Electronic Annotation more info
involved_in regulation of blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info

General protein information

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Preferred Names: urotensin-2B

Names: prepro-URP; urotensin 2 domain containing; urotensin II-related peptide; urotensin IIB; urotensin-2 domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198152.5 → NP_937795.2 urotensin-2B precursor

Status: VALIDATED

Source sequence(s)

AC068645, AC126567

Consensus CDS

CCDS3300.1

UniProtKB/Swiss-Prot

B3KQY8, D3DNW1, Q2M1Z2, Q765I0

Related

ENSP00000340526.5, ENST00000340524.10

Conserved Domains (1) summary

PLN02531
Location:89 → 116

PLN02531; GTP cyclohydrolase I