U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MXRA8 matrix remodeling associated 8 [ Homo sapiens (human) ]

    Gene ID: 54587, updated on 10-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    MXRA8provided by HGNC
    Official Full Name
    matrix remodeling associated 8provided by HGNC
    Primary source
    HGNC:HGNC:7542
    See related
    Ensembl:ENSG00000162576 MIM:617293; AllianceGenome:HGNC:7542
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ASP3
    Summary
    Predicted to be involved in establishment of glial blood-brain barrier. Located in extracellular exosome. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in gall bladder (RPKM 26.7), fat (RPKM 25.8) and 22 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MXRA8 in Genome Data Viewer
    Location:
    1p36.33
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1352689..1363541, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (783235..794097, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1288069..1298921, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene taste 1 receptor member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 61 Neighboring gene dishevelled segment polarity protein 1 Neighboring gene microRNA 6808 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1281421-1282299 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1282501-1283130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1283131-1283760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 62 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 63 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 64 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1288877-1289508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1289509-1290140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1290141-1290771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1291896-1292448 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1293036-1293618 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 65 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 66 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1307318-1308085 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 67 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1310373-1311278 Neighboring gene aurora kinase A interacting protein 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 8

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Loss of MXRA8 Delays Mammary Tumor Development and Impairs Metastasis. Simpson KE, et al. Int J Mol Sci, 2023 Sep 6. PMID 37762032, Free PMC Article
    2. Single-cell RNA combined with bulk RNA analysis to explore oxidative stress and energy metabolism factors and found a new prostate cancer oncogene MXRA8. Miao M, et al. Aging (Albany NY), 2024 Mar 4. PMID 38441550, Free PMC Article
    3. Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein. Song H, et al. Cell, 2019 Jun 13. PMID 31080063
    4. Cryo-EM Structure of Chikungunya Virus in Complex with the Mxra8 Receptor. Basore K, et al. Cell, 2019 Jun 13. PMID 31080061, Free PMC Article
    5. Elevated Expression of miR-200c/141 in MDA-MB-231 Cells Suppresses MXRA8 Levels and Impairs Breast Cancer Growth and Metastasis In Vivo. Simpson KE, et al. Genes (Basel), 2022 Apr 14. PMID 35456497, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Single-cell RNA combined with bulk RNA analysis to explore oxidative stress and energy metabolism factors and found a new prostate cancer oncogene MXRA8.
      Title: Single-cell RNA combined with bulk RNA analysis to explore oxidative stress and energy metabolism factors and found a new prostate cancer oncogene MXRA8.
    2. Loss of MXRA8 Delays Mammary Tumor Development and Impairs Metastasis.
      Title: Loss of MXRA8 Delays Mammary Tumor Development and Impairs Metastasis.
    3. Elevated Expression of miR-200c/141 in MDA-MB-231 Cells Suppresses MXRA8 Levels and Impairs Breast Cancer Growth and Metastasis In Vivo.
      Title: Elevated Expression of miR-200c/141 in MDA-MB-231 Cells Suppresses MXRA8 Levels and Impairs Breast Cancer Growth and Metastasis In Vivo.
    4. the stalk region of MXRA8 is critical for CHIKV virus entry.
      Title: Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein.
    5. studies provide insight into how Mxra8 binds CHIKV and creates a path for developing alphavirus entry inhibitors.
      Title: Cryo-EM Structure of Chikungunya Virus in Complex with the Mxra8 Receptor.
    6. exogenous expression of DICAM in human umbilical vein endothelial cells suppressed angiogenesis in vitro Matrigel and in vivo plug assays, and conversely, DICAM knockdown enhanced angiogenesis
      Title: DICAM inhibits angiogenesis via suppression of AKT and p38 MAP kinase signalling.
    7. MXRA8 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
      Title: The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
    8. new member of the transmembrane-type immunoglobulin superfamily and designated limitrin, localizing selectively to glia limitans in mouse brain
      Title: Limitrin, a novel immunoglobulin superfamily protein localized to glia limitans formed by astrocyte endfeet.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC3047, DKFZp586E2023

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of glial blood-brain barrier ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in ciliary membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    matrix remodeling-associated protein 8
    Names
    limitrin
    matrix-remodeling-associated protein 8
    matrix-remodelling associated 8

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282582.2 → NP_001269511.1  matrix remodeling-associated protein 8 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001269511.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in both UTRs and uses an alternate splice site in the 3' terminal exon compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1. Variants 2 and 5 encode the same isoform (2).
      Source sequence(s)
      AL139287
      Consensus CDS
      CCDS24.1
      UniProtKB/Swiss-Prot
      B3KTR6, B4DE34, Q5TA39, Q96KC3, Q9BRK3
      Conserved Domains (1) summary
      pfam07686
      Location:172 → 291
      V-set; Immunoglobulin V-set domain

    2. NM_001282583.2 → NP_001269512.1  matrix remodeling-associated protein 8 isoform 4

      See identical proteins and their annotated locations for NP_001269512.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in both UTRs and has multiple coding region differences compared to variant 1. The encoded isoform (4) is shorter and has distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      AL139287
      Consensus CDS
      CCDS59952.1
      Related
      ENSP00000436135.1, ENST00000477278.3
      Conserved Domains (1) summary
      pfam07686
      Location:163 → 282
      V-set; Immunoglobulin V-set domain

    3. NM_001282584.2 → NP_001269513.1  matrix remodeling-associated protein 8 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001269513.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in both UTRs and has multiple coding region differences compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL139287
      Consensus CDS
      CCDS59950.1
      UniProtKB/Swiss-Prot
      Q9BRK3
      Related
      ENSP00000344998.4, ENST00000342753.8
      Conserved Domains (1) summary
      pfam07686
      Location:71 → 190
      V-set; Immunoglobulin V-set domain

    4. NM_001282585.1 → NP_001269514.1  matrix remodeling-associated protein 8 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK027269, AL139287, DC356331
      Consensus CDS
      CCDS59951.1
      Related
      ENSP00000399229.2, ENST00000445648.5
      Conserved Domains (1) summary
      pfam07686
      Location:172 → 291
      V-set; Immunoglobulin V-set domain

    5. NM_032348.4 → NP_115724.1  matrix remodeling-associated protein 8 isoform 2 precursor

      See identical proteins and their annotated locations for NP_115724.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in both UTRs and uses two alternate splice sites in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1. Variants 2 and 5 encode the same isoform (2).
      Source sequence(s)
      AL139287
      Consensus CDS
      CCDS24.1
      UniProtKB/Swiss-Prot
      B3KTR6, B4DE34, Q5TA39, Q96KC3, Q9BRK3
      Related
      ENSP00000307887.6, ENST00000309212.11
      Conserved Domains (1) summary
      pfam07686
      Location:172 → 291
      V-set; Immunoglobulin V-set domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      1352689..1363541 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017001517.2 → XP_016857006.1  matrix remodeling-associated protein 8 isoform X2

    2. XM_017001516.3 → XP_016857005.1  matrix remodeling-associated protein 8 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      783235..794097 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337161.1 → XP_054193136.1  matrix remodeling-associated protein 8 isoform X2

    2. XM_054337160.1 → XP_054193135.1  matrix remodeling-associated protein 8 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BRK3.1 GenPept UniProtKB/Swiss-Prot:Q9BRK3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous