Npr1 natriuretic peptide receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Npr1provided by RGD
Official Full Name: natriuretic peptide receptor 1provided by RGD
Primary source: RGD:3195
See related: EnsemblRapid:ENSRNOG00000014684 AllianceGenome:RGD:3195
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gca; Npra; Anpra; NPR-A
Summary: Enables guanylate cyclase activity. Involved in several processes, including cGMP-mediated signaling; positive regulation of cGMP-mediated signaling; and receptor guanylyl cyclase signaling pathway. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human NPR1 (natriuretic peptide receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 223.9), Lung (RPKM 119.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (178231766..178247591, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (175934181..175950118, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (189840403..189857032, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Triiodo-L-thyronine (T3) downregulates Npr1 gene (coding for natriuretic peptide receptor-A) transcription in H9c2 cells: involvement of beta-AR-ROS signaling.
Title: Triiodo-L-thyronine (T3) downregulates Npr1 gene (coding for natriuretic peptide receptor-A) transcription in H9c2 cells: involvement of β-AR-ROS signaling.
Endothelial Natriuretic Peptide Receptor 1 Play Crucial Role for Acute and Chronic Blood Pressure Regulation by Atrial Natriuretic Peptide.
Title: Endothelial Natriuretic Peptide Receptor 1 Play Crucial Role for Acute and Chronic Blood Pressure Regulation by Atrial Natriuretic Peptide.
Atenolol treatment normalized the altered expression of Npr1 and Npr2 genes.
Title: Differential expression and regulation of anti-hypertrophic genes Npr1 and Npr2 during β-adrenergic receptor activation-induced hypertrophic growth in rats.
Suppression of Npr1, not Npr2 gene function induces hypertrophic growth in cardiomyocytes in vitro.
Title: Suppression of Npr1, not Npr2 gene function induces hypertrophic growth in H9c2 cells in vitro.
The results suggest that an antagonistic cascade exists between the TGF-beta1/Smad/deltaEF1 pathways and Npr1 expression and receptor signaling that is relevant to renal and vascular remodeling, and may be critical in the regulation of blood pressure and cardiovascular homeostasis.
Title: Transforming growth factor β1 antagonizes the transcription, expression and vascular signaling of guanylyl cyclase/natriuretic peptide receptor A - role of δEF1.
augmentation of inhibitory effect on basal motility by ANP in experimental colitis may be due an increased expression of colonic natriuretic peptide receptor-A mRNA
Title: Modulation in Natriuretic Peptides System in Experimental Colitis in Rats.
Provide direct evidence for the presence and synthesis of ANP and its receptors in both neuronal and non-neuronal cells within the cochlear spiral ganglion.
Title: Expression patterns of atrial natriuretic peptide and its receptors within the cochlear spiral ganglion of the postnatal rat.
Angiotensin-II down-regulates cardiac natriuretic peptide receptor-A mediated anti-hypertrophic signaling in experimental rat hearts
Title: Angiotensin-II down-regulates cardiac natriuretic peptide receptor-A mediated anti-hypertrophic signaling in experimental rat hearts.
BNP and NPR-A are expressed in the dorsal horn ganglion, and expressions are elevated in rats with chronic nonbacterial prostatitis.
Title: [Expressions of BNP and NPR-A in rat models of chronic nonbacterial prostatitis and their significance].
knockdown of NPR-A up-regulates the expression of NPR-C, Gialpha proteins, and NPR-C-linked adenylyl cyclase signalling and suggests a cross-talk between NPR-A and NPR-C.
Title: Knockdown of natriuretic peptide receptor-A enhances receptor C expression and signalling in vascular smooth muscle cells.

Submit: New GeneRIF Correction See all GeneRIFs (33)

General gene information

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Markers

RH132833 (e-PCR)
- UniSTS:216116

Npr1 (e-PCR), detects polymorphism
- UniSTS:525461

D2Wox24 (e-PCR)
- UniSTS:240038

D2Arb44 (e-PCR)
- UniSTS:240577

D2Mit21 (e-PCR), detects polymorphism
- UniSTS:227321

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables guanylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables guanylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables hormone binding	ISO Inferred from Sequence Orthology more info
enables natriuretic peptide receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphorus-oxygen lyase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in blood vessel diameter maintenance	IEA Inferred from Electronic Annotation more info
involved_in cGMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cGMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cGMP-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dopamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cGMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor guanylyl cyclase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor guanylyl cyclase signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor guanylyl cyclase signaling pathway	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: atrial natriuretic peptide receptor 1

Names: ANP-A; ANPR-A; GC-A; atrial natriuretic peptide A-type receptor; atrial natriuretic peptide receptor A; atrial natriuretic peptide receptor type A; guanylate cyclase A; natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)

NP_036745.1

EC 4.6.1.2

XP_006232653.1

EC 4.6.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012613.1 → NP_036745.1 atrial natriuretic peptide receptor 1 precursor

Status: PROVISIONAL

Source sequence(s)

J05677

UniProtKB/Swiss-Prot

A1A5N8, P18910

UniProtKB/TrEMBL

A0A8I5ZSQ4, A6J6M1

Related

ENSRNOP00000020307.3, ENSRNOT00000020307.5

Conserved Domains (7) summary

cd06385
Location:32 → 439

PBP1_NPR_A; Ligand-binding domain of type A natriuretic peptide receptor

smart00219
Location:543 → 797

TyrKc; Tyrosine kinase, catalytic domain

smart00044
Location:836 → 1025

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

cd14042
Location:530 → 803

PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B

pfam00211
Location:863 → 1049

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam01094
Location:50 → 410

ANF_receptor; Receptor family ligand binding region

pfam07701
Location:812 → 857

HNOBA; Heme NO binding associated

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

178231766..178247591 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006232591.5 → XP_006232653.1 atrial natriuretic peptide receptor 1 isoform X1

UniProtKB/Swiss-Prot

A1A5N8, P18910

UniProtKB/TrEMBL

A0A8I5ZSQ4, A6J6M1

Conserved Domains (7) summary

cd06385
Location:32 → 439

PBP1_NPR_A; Ligand-binding domain of type A natriuretic peptide receptor

smart00219
Location:543 → 797

TyrKc; Tyrosine kinase, catalytic domain

smart00044
Location:836 → 1025

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

cd14042
Location:530 → 803

PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B

pfam00211
Location:863 → 1049

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam01094
Location:50 → 410

ANF_receptor; Receptor family ligand binding region

pfam07701
Location:812 → 857

HNOBA; Heme NO binding associated