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    Cryl1 crystallin, lambda 1 [ Mus musculus (house mouse) ]

    Gene ID: 68631, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cryl1provided by MGI
    Official Full Name
    crystallin, lambda 1provided by MGI
    Primary source
    MGI:MGI:1915881
    See related
    Ensembl:ENSMUSG00000021947 AllianceGenome:MGI:1915881
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    gul3dh; 1110025H08Rik; A230106J09Rik
    Summary
    Predicted to enable L-gulonate 3-dehydrogenase activity; NAD+ binding activity; and protein homodimerization activity. Involved in D-glucuronate catabolic process to D-xylulose 5-phosphate. Is active in cytosol. Is expressed in several structures, including alimentary system; hemolymphoid system; metanephros; nose; and secondary oocyte. Orthologous to human CRYL1 (crystallin lambda 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney adult (RPKM 161.7), duodenum adult (RPKM 56.6) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cryl1 in Genome Data Viewer
    Location:
    14 C3; 14 30.1 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (57512491..57635940, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (57275034..57398483, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene gap junction protein, beta 6 Neighboring gene predicted gene 8996 Neighboring gene predicted gene, 23593 Neighboring gene predicted gene 8971 Neighboring gene STARR-positive B cell enhancer ABC_E1897 Neighboring gene predicted gene, 41161 Neighboring gene predicted gene, 29717 Neighboring gene STARR-seq mESC enhancer starr_36807 Neighboring gene intraflagellar transport 88 Neighboring gene STARR-positive B cell enhancer ABC_E5444 Neighboring gene STARR-positive B cell enhancer mm9_chr14:58144327-58144627 Neighboring gene STARR-seq mESC enhancer starr_36808 Neighboring gene interleukin 17D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural and functional characterization of rabbit and human L-gulonate 3-dehydrogenase. Ishikura S, et al. J Biochem, 2005 Mar. PMID 15809331
    2. Studies on dehydrogenases of the glucuronate-xylulose cycle in the livers of diabetic mice and rats. Tulsiani DR, et al. Diabetes, 1979 Sep. PMID 38160
    3. Human CRYL1, a novel enzyme-crystallin overexpressed in liver and kidney and downregulated in 58% of liver cancer tissues from 60 Chinese patients, and four new homologs from other mammalians. Chen J, et al. Gene, 2003 Jan 2. PMID 12527201
    4. Identification of candidate maternal-effect genes through comparison of multiple microarray data sets. Mager J, et al. Mamm Genome, 2006 Sep. PMID 16964442
    5. Gene discovery by microarray: identification of novel genes induced during growth factor-mediated muscle cell survival and differentiation. Kuninger D, et al. Genomics, 2004 Nov. PMID 15475267

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-gulonate 3-dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-gulonate 3-dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables L-gulonate 3-dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables NAD+ binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NAD+ binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-glucuronate catabolic process to D-xylulose 5-phosphate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    lambda-crystallin homolog
    Names
    L-gulonate 3-dehydrogenase
    crystallin, lamda 1
    NP_084280.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030004.3 → NP_084280.2  lambda-crystallin homolog

      See identical proteins and their annotated locations for NP_084280.2

      Status: PROVISIONAL

      Source sequence(s)
      CT010506
      Consensus CDS
      CCDS27155.1
      UniProtKB/Swiss-Prot
      Q542R9, Q8R4W7, Q99KP3
      UniProtKB/TrEMBL
      A7VMV2
      Related
      ENSMUSP00000022517.8, ENSMUST00000022517.9
      Conserved Domains (3) summary
      PRK06129
      Location:9 → 313
      PRK06129; 3-hydroxyacyl-CoA dehydrogenase; Validated
      pfam00725
      Location:192 → 259
      3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
      pfam02737
      Location:9 → 186
      3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      57512491..57635940 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99KP3.3 GenPept UniProtKB/Swiss-Prot:Q99KP3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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