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    Fbxo31 F-box protein 31 [ Mus musculus (house mouse) ]

    Gene ID: 76454, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fbxo31provided by MGI
    Official Full Name
    F-box protein 31provided by MGI
    Primary source
    MGI:MGI:1354708
    See related
    Ensembl:ENSMUSG00000052934 AllianceGenome:MGI:1354708
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fbx14; Fbxo14; 1110003O08Rik; 2310046N15Rik
    Summary
    Predicted to enable cyclin binding activity. Predicted to be involved in several processes, including mitotic G1 DNA damage checkpoint signaling; positive regulation of dendrite morphogenesis; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in neuronal cell body. Is expressed in several structures, including adrenal gland; brain; early embryo; genitourinary system; and gut gland. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 45. Orthologous to human FBXO31 (F-box protein 31). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 24.3), cortex adult (RPKM 21.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fbxo31 in Genome Data Viewer
    Location:
    8 E1; 8 70.65 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (122276182..122305607, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (121549443..121578864, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700018B08 gene Neighboring gene RIKEN cDNA 1700030M09 gene Neighboring gene STARR-positive B cell enhancer ABC_E2276 Neighboring gene nuclear encoded tRNA methionine 17 (anticodon CAT) Neighboring gene predicted gene, 17786

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aberrantly High FBXO31 Impairs Oocyte Quality in Premature Ovarian Insufficiency. Zhao F, et al. Aging Dis, 2024 Apr 1. PMID 37611899, Free PMC Article
    2. Truncation of the E3 ubiquitin ligase component FBXO31 causes non-syndromic autosomal recessive intellectual disability in a Pakistani family. Mir A, et al. Hum Genet, 2014 Aug. PMID 24623383
    3. A family of mammalian F-box proteins. Winston JT, et al. Curr Biol, 1999 Oct 21. PMID 10531037
    4. Deterministic and stochastic allele specific gene expression in single mouse blastomeres. Tang F, et al. PLoS One, 2011. PMID 21731673, Free PMC Article
    5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aberrantly High FBXO31 Impairs Oocyte Quality in Premature Ovarian Insufficiency.
      Title: Aberrantly High FBXO31 Impairs Oocyte Quality in Premature Ovarian Insufficiency.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic G1 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic G1 DNA damage checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    F-box only protein 31
    Names
    F-box only protein 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414923.1 → NP_001401852.1  F-box only protein 31 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122205, AC182458

    2. NM_001414924.1 → NP_001401853.1  F-box only protein 31 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122205, AC182458

    3. NM_001414925.1 → NP_001401854.1  F-box only protein 31 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC122205, AC182458

    4. NM_133765.5 → NP_598526.3  F-box only protein 31 isoform 1

      See identical proteins and their annotated locations for NP_598526.3

      Status: VALIDATED

      Source sequence(s)
      AC122205, AC182458
      Consensus CDS
      CCDS52693.1
      UniProtKB/Swiss-Prot
      Q3TQF0, Q8K1A7, Q9JJC4
      Related
      ENSMUSP00000057573.6, ENSMUST00000059018.14
      Conserved Domains (2) summary
      pfam12014
      Location:271 → 329
      DUF3506; Domain of unknown function (DUF3506)
      pfam12937
      Location:61 → 99
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      122276182..122305607 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004934896.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TQF0.1 GenPept UniProtKB/Swiss-Prot:Q3TQF0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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