Kctd9 potassium channel tetramerisation domain containing 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kctd9provided by MGI
Official Full Name: potassium channel tetramerisation domain containing 9provided by MGI
Primary source: MGI:MGI:2145579
See related: Ensembl:ENSMUSG00000034327 AllianceGenome:MGI:2145579
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable cullin family protein binding activity and identical protein binding activity. Predicted to be involved in intracellular signal transduction; protein homooligomerization; and protein ubiquitination. Is expressed in brain. Orthologous to human KCTD9 (potassium channel tetramerization domain containing 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 5.9), bladder adult (RPKM 5.3) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D1; 14 34.66 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (67953536..67979760)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (67716086..67742310)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kctd9 Deficiency Impairs Natural Killer Cell Development and Effector Function.
Title: Kctd9 Deficiency Impairs Natural Killer Cell Development and Effector Function.
Interference with potassium channel tetramerisation domain containing 9 (KCTD9) expression exert beneficial effect in viral fulminant hepatitis therapy, which may be mediated by impairment of NK cell activation.
Title: Interference with KCTD9 inhibits NK cell activation and ameliorates fulminant liver failure in mice.
A novel potassium channel gene KCTD9 was highly expressed in hepatic NK cells and T cells of fulminant hepatitis mice induced by MHV-3.
Title: [KCTD9, a novel potassium channel related gene, was highly expressed in hepatic NK cells and T cells of fulminant hepatitis mice induced by MHV-3].

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

20.MMHAP9FRG8.seq (e-PCR)
- UniSTS:123502

RH124352 (e-PCR)
- UniSTS:161174

AI854539 (e-PCR)
- UniSTS:180687

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cullin family protein binding	ISO Inferred from Sequence Orthology more info
enables cullin family protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: BTB/POZ domain-containing protein KCTD9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001111028.1 → NP_001104498.1 BTB/POZ domain-containing protein KCTD9 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AI854539, AK087312, AK158922

Consensus CDS

CCDS49531.1

UniProtKB/TrEMBL

A0AA74KUV6, E9PUA6

Related

ENSMUSP00000114489.2, ENSMUST00000150768.8

Conserved Domains (5) summary

smart00225
Location:90 → 191

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00805
Location:338 → 377

Pentapeptide; Pentapeptide repeats (8 copies)

pfam11834
Location:2 → 64

KHA; KHA, dimerization domain of potassium ion channel

pfam13599
Location:310 → 384

Pentapeptide_4; Pentapeptide repeats (9 copies)

cl02518
Location:91 → 181

BTB; BTB/POZ domain
NM_001285933.1 → NP_001272862.1 BTB/POZ domain-containing protein KCTD9 isoform c

See identical proteins and their annotated locations for NP_001272862.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation from a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.

Source sequence(s)

AI854539, AK087312, AK158922

UniProtKB/Swiss-Prot

Q80UN1

Conserved Domains (2) summary

COG1357
Location:54 → 264

YjbI; Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown]

cl38908
Location:1 → 74

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
NM_134073.2 → NP_598834.2 BTB/POZ domain-containing protein KCTD9 isoform b

See identical proteins and their annotated locations for NP_598834.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.

Source sequence(s)

AI854539, AK158922

Consensus CDS

CCDS27230.2

UniProtKB/Swiss-Prot

Q3TLH9, Q3TY35, Q80UN1

Related

ENSMUSP00000077200.7, ENSMUST00000078053.13

Conserved Domains (5) summary

smart00225
Location:90 → 191

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00805
Location:288 → 327

Pentapeptide; Pentapeptide repeats (8 copies)

pfam11834
Location:2 → 64

KHA; KHA, dimerization domain of potassium ion channel

pfam13599
Location:260 → 334

Pentapeptide_4; Pentapeptide repeats (9 copies)

cl02518
Location:91 → 181

BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

67953536..67979760

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006518343.4 → XP_006518406.1 BTB/POZ domain-containing protein KCTD9 isoform X1

See identical proteins and their annotated locations for XP_006518406.1

Related

ENSMUSP00000120440.2, ENSMUST00000152243.8

Conserved Domains (2) summary

COG1357
Location:54 → 264

YjbI; Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown]

cl38908
Location:1 → 74

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily