Ccn5 cellular communication network factor 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccn5provided by MGI
Official Full Name: cellular communication network factor 5provided by MGI
Primary source: MGI:MGI:1328326
See related: Ensembl:ENSMUSG00000027656 AllianceGenome:MGI:1328326
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Crgr4; Ctgfl; Rcop1; Wisp2
Summary: Predicted to enable growth factor activity; heparin binding activity; and integrin binding activity. Acts upstream of or within regulation of cell growth. Located in extracellular space; nucleus; and plasma membrane. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; long bone epiphyseal plate; and respiratory system. Orthologous to human CCN5 (cellular communication network factor 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in lung adult (RPKM 28.7), ovary adult (RPKM 25.3) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 84.49 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (163662724..163675066)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (163820752..163833146)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Modified mRNA-Mediated CCN5 Gene Transfer Ameliorates Cardiac Dysfunction and Fibrosis without Adverse Structural Remodeling.
Title: Modified mRNA-Mediated CCN5 Gene Transfer Ameliorates Cardiac Dysfunction and Fibrosis without Adverse Structural Remodeling.
The matricellular protein CCN5 prevents adverse atrial structural and electrical remodelling.
Title: The matricellular protein CCN5 prevents adverse atrial structural and electrical remodelling.
these data suggest that down-regulation of CCN5 is associated with fibrotic deformation of Retinal pigment epithelium (RPE) under pathological conditions and that restoration of the CCN5 level effectively promotes recovery of deformed RPE.
Title: The matricellular protein CCN5 inhibits fibrotic deformation of retinal pigment epithelium.
Knockout (KO) of CCN5, which encodes a matricellular protein, caused mild obesity. The CCN5 KO mice also exhibited mild diabetes characterized by high fasting glucose levels and impaired insulin and glucose tolerances. Cardiac hypertrophy, ectopic lipid accumulation, and impaired lipid metabolism in hearts were observed in CCN5 KO.
Title: CCN5 knockout mice exhibit lipotoxic cardiomyopathy with mild obesity and diabetes.
WISP2 is a novel secreted adipokine, most highly expressed in the subcutaneous adipose tissue and primarily in mesenchymal precursor cells. WISP2 is, to the best of our knowledge, the first identified endogenous and secreted autocrine/endocrine regulator of adipose tissue and heart/muscle cellularity and growth.
Title: Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance.
Insulin-like growth factor (IGF)-1 elicited clear stimulation of WNT1 inducible signaling pathway protein 2 (CCN5/WISP2) mRNA and protein levels in cultured islets.
Title: Role of CCN5 (WNT1 inducible signaling pathway protein 2) in pancreatic islets.
Data suggest that CCN5, minimally expressed in unstimulated islet beta-cells, is strongly and directly induced by Igf1 (insulin-like growth factor I); overexpression of CCN5 stimulates cell proliferation and inhibits streptozotocin-induced apoptosis.
Title: IGF-I stimulates CCN5/WISP2 gene expression in pancreatic β-cells, which promotes cell proliferation and survival against streptozotocin.
These results suggested that secreted Wisp2/CCN5 induces Akt and ERK phosphorylation via integrins, and consequently facilitates neurite formation and conferred resistance to apoptosis.
Title: Wisp2/CCN5 up-regulated in the central nervous system of GM3-only mice facilitates neurite formation in Neuro2a cells via integrin-Akt signaling.
CCN2 is pro-hypertrophic and -fibrotic, whereas CCN5 is anti-hypertrophic and -fibrotic.
Title: The opposing effects of CCN2 and CCN5 on the development of cardiac hypertrophy and fibrosis.
Although WISP-2 is a downstream protein of Wnt signaling, the role of WISP-2 on adipocyte differentiation may be marginal, at least in this in vitro culture model.
Title: Effect of Wnt-1 inducible signaling pathway protein-2 (WISP-2/CCN5), a downstream protein of Wnt signaling, on adipocyte differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2)

General gene information

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Markers

Wisp2 (e-PCR), detects polymorphism
- UniSTS:527128

PMC293470P1 (e-PCR)
- UniSTS:272450

PMC124275P3 (e-PCR)
- UniSTS:270461

Wisp2 (e-PCR), detects polymorphism
- UniSTS:532697

AF100778 (e-PCR)
- UniSTS:163303

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables growth factor activity	ISA Inferred from Sequence Alignment more info	PubMed
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in podosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CCN family member 5

Names: CTGF-L; WISP-2; WNT1 inducible signaling pathway protein 2; connective tissue growth factor-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016873.2 → NP_058569.2 CCN family member 5 precursor

See identical proteins and their annotated locations for NP_058569.2

Status: VALIDATED

Source sequence(s)

AL731698, BC032877, BQ560868

Consensus CDS

CCDS17016.1

UniProtKB/Swiss-Prot

Q8CIC8, Q9Z0G4

UniProtKB/TrEMBL

A2AHD1

Related

ENSMUSP00000029188.8, ENSMUST00000029188.8

Conserved Domains (2) summary

smart00214
Location:100 → 159

VWC; von Willebrand factor (vWF) type C domain

pfam00219
Location:26 → 78

IGFBP; Insulin-like growth factor binding protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

163662724..163675066

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499169.4 → XP_006499232.1 CCN family member 5 isoform X1

Conserved Domains (2) summary

cl17735
Location:100 → 159

VWC; von Willebrand factor type C domain

pfam00219
Location:26 → 78

IGFBP; Insulin-like growth factor binding protein