Kcnd1 potassium voltage-gated channel, Shal-related family, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnd1provided by MGI
Official Full Name: potassium voltage-gated channel, Shal-related family, member 1provided by MGI
Primary source: MGI:MGI:96671
See related: Ensembl:ENSMUSG00000009731 AllianceGenome:MGI:96671
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Shal; Kv4.1; Shal1; Kca2-1; mShal1; 1110037K09Rik
Summary: This gene encodes a multipass transmembrane protein that comprises a subunit of voltage-gated rapidly inactivating A-type potassium channels. [provided by RefSeq, May 2015]
Expression: Broad expression in genital fat pad adult (RPKM 5.4), frontal lobe adult (RPKM 2.2) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A1.1; X 3.53 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (7686907..7704517)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (7823759..7838278)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Calbindin regulates Kv4.1 trafficking and excitability in dentate granule cells via CaMKII-dependent phosphorylation.
Title: Calbindin regulates Kv4.1 trafficking and excitability in dentate granule cells via CaMKII-dependent phosphorylation.
Impaired pattern separation in Tg2576 mice is associated with hyperexcitable dentate gyrus caused by Kv4.1 downregulation.
Title: Impaired pattern separation in Tg2576 mice is associated with hyperexcitable dentate gyrus caused by Kv4.1 downregulation.
Kv4.1, a Key Ion Channel For Low Frequency Firing of Dentate Granule Cells, Is Crucial for Pattern Separation.
Title: Kv4.1, a Key Ion Channel For Low Frequency Firing of Dentate Granule Cells, Is Crucial for Pattern Separation.
Expression of the Kv4.1-targeted shRNA significantly decreased interspike intervals and increased repetitive firing rates in suprachiasmatic nucleus (SCN) neurons during the day and at night. results presented here also revealed that the acute knockdown of Kv4.1 had differential effects on the daytime and nighttime input resistance and repetitive firing rates in SCN neurons.
Title: Acute Knockdown of Kv4.1 Regulates Repetitive Firing Rates and Clock Gene Expression in the Suprachiasmatic Nucleus and Daily Rhythms in Locomotor Behavior.
The complex voltage-dependent gating rearrangements of eukaryotic Kv channels are not limited to the membrane-spanning core but must include the intracellular T1-T1 interface.
Title: Voltage-dependent gating rearrangements in the intracellular T1-T1 interface of a K+ channel.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

DXImx3 (e-PCR), detects polymorphism
- UniSTS:181867

PMC125678P2 (e-PCR)
- UniSTS:270505

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables A-type (transient outward) potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables A-type (transient outward) potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: A-type voltage-gated potassium channel KCND1; potassium voltage-gated channel subfamily D member 1

Names: voltage-gated potassium channel subunit Kv4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008423.2 → NP_032449.1 A-type voltage-gated potassium channel KCND1

See identical proteins and their annotated locations for NP_032449.1

Status: REVIEWED

Source sequence(s)

AK033805, BC139325

Consensus CDS

CCDS29974.1

UniProtKB/Swiss-Prot

Q03719, Q8CC68

UniProtKB/TrEMBL

A2AEX0

Related

ENSMUSP00000009875.5, ENSMUST00000009875.5

Conserved Domains (3) summary

cl38908
Location:6 → 143

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:185 → 417

Ion_trans; Ion transport protein

pfam11879
Location:447 → 550

DUF3399; Domain of unknown function (DUF3399)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

7686907..7704517

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161827.1 → XP_036017720.1 potassium voltage-gated channel subfamily D member 1 isoform X1

UniProtKB/Swiss-Prot

Q03719, Q8CC68

UniProtKB/TrEMBL

A2AEX0

Conserved Domains (3) summary

cl38908
Location:6 → 143

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:185 → 417

Ion_trans; Ion transport protein

pfam11879
Location:447 → 550

DUF3399; Domain of unknown function (DUF3399)