Hrh2 histamine receptor H2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hrh2provided by MGI
Official Full Name: histamine receptor H2provided by MGI
Primary source: MGI:MGI:108482
See related: Ensembl:ENSMUSG00000034987 AllianceGenome:MGI:108482
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: H2R; HH2R
Summary: Predicted to enable heterocyclic compound binding activity; histamine receptor activity; and neurotransmitter receptor activity. Acts upstream of or within several processes, including epithelial cell morphogenesis; gastric acid secretion; and learning or memory. Predicted to be active in dendrite and plasma membrane. Is expressed in brain; early conceptus; stomach; and uterus. Orthologous to human HRH2 (histamine receptor H2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in frontal lobe adult (RPKM 1.9), stomach adult (RPKM 1.8) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B1; 13 28.4 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (54345990..54390201)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (54191970..54236182)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Histamine H2 receptor deficit in glutamatergic neurons contributes to the pathogenesis of schizophrenia.
Title: Histamine H(2) receptor deficit in glutamatergic neurons contributes to the pathogenesis of schizophrenia.
Generation and identification of endothelial-specific Hrh2 knockout mice.
Title: Generation and identification of endothelial-specific Hrh2 knockout mice.
Histamine H2 receptor negatively regulates oligodendrocyte differentiation in neonatal hypoxic-ischemic white matter injury.
Title: Histamine H2 receptor negatively regulates oligodendrocyte differentiation in neonatal hypoxic-ischemic white matter injury.
These data suggest that Hrh2 signaling is required for effective phagocytosis by regulating the process of autophagy and scavenger receptor MSR1 abundance in macrophages.
Title: Phagocytosis by macrophages depends on histamine H2 receptor signaling and scavenger receptor 1.
The deliberate activation of H2 R, or its downstream signaling molecules, may represent a novel therapeutic target for chronic lung inflammatory diseases, especially when CD1d-mediated presentation of lipid antigens to iNKT cells is contributing to the pathology.
Title: Histamine receptor 2 modifies iNKT cell activity within the inflamed lung.
Ability of probiotic L. reuteri to suppress colitis depends on the presence of a bacterial histidine decarboxylase gene(s) in the intestinal microbiome, consumption of a histidine-containing diet, and signaling via the histamine H2 receptor (H2R).
Title: Histamine H2 Receptor-Mediated Suppression of Intestinal Inflammation by Probiotic Lactobacillus reuteri.
required for IL-6 and IL-17 mucosal responses to intestinal histamine-secreting microbes
Title: Histamine receptor 2 is a key influence in immune responses to intestinal histamine-secreting microbes.
histamine facilitates memory retention of inhibitory avoidance in mice, non-linearly by H2 receptor activation
Title: Intra-cerebellar microinjection of histamine enhances memory consolidation of inhibitory avoidance learning in mice via H2 receptors.
histamine receptor H1 and histamine receptor H2 reciprocally regulate inflammation in the ligation-induced arteriosclerosis
Title: Histamine receptors expressed in circulating progenitor cells have reciprocal actions in ligation-induced arteriosclerosis.
Data show that experimental allergic encephalomyelitis (EAE) severity and in histamine H2 receptor (H2RKO) mice expressing H2R exclusively in T cells become equal to those in wild-type B6 mice only when pertussis toxin is used to elicit disease.
Title: Histamine H₂ receptor signaling × environment interactions determine susceptibility to experimental allergic encephalomyelitis.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Markers

Hrh2 (e-PCR), detects polymorphism
- UniSTS:164925

NoName (e-PCR)
- UniSTS:489069

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heterocyclic compound binding	ISO Inferred from Sequence Orthology more info
enables histamine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables histamine receptor activity	IEA Inferred from Electronic Annotation more info
enables histamine receptor activity	ISO Inferred from Sequence Orthology more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gastric acid secretion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within gastrin-induced gastric acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within histamine-induced gastric acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of arachidonate secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histamine H2 receptor

Names: gastric receptor I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001010973.3 → NP_001010973.1 histamine H2 receptor isoform 1

See identical proteins and their annotated locations for NP_001010973.1

Status: VALIDATED

Source sequence(s)

AC163343, AC164086

Consensus CDS

CCDS26526.1

UniProtKB/Swiss-Prot

P97292, Q9D282

UniProtKB/TrEMBL

Q9QX37

Related

ENSMUSP00000038170.4, ENSMUST00000038101.4

Conserved Domains (1) summary

cd15051
Location:19 → 298

7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001413010.1 → NP_001399939.1 histamine H2 receptor isoform 3

Status: VALIDATED

Source sequence(s)

AC163343, AC164086

UniProtKB/TrEMBL

A0A1B0GSX9, Q9QX37

Related

ENSMUSP00000148117.2, ENSMUST00000209846.2

RNA

NR_153432.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC163343, AC164086

Related

ENSMUST00000211742.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

54345990..54390201

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157857.1 → XP_036013750.1 histamine H2 receptor isoform X2

Conserved Domains (2) summary

cd14964
Location:40 → 70

7tm_GPCRs; TM helix 6 [structural motif]

cl28897
Location:2 → 112

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_036157856.1 → XP_036013749.1 histamine H2 receptor isoform X1

UniProtKB/TrEMBL

A0A1B0GSX9, Q9QX37

Conserved Domains (1) summary

cd15051
Location:19 → 298

7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_008286.2: Suppressed sequence

Description

NM_008286.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.