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    Cnbd2 cyclic nucleotide binding domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 70873, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cnbd2provided by MGI
    Official Full Name
    cyclic nucleotide binding domain containing 2provided by MGI
    Primary source
    MGI:MGI:1918123
    See related
    Ensembl:ENSMUSG00000038085 AllianceGenome:MGI:1918123
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cris; 4921517L17Rik; 5430421B09Rik
    Summary
    Enables cAMP binding activity. Acts upstream of or within spermatogenesis. Located in cytosol. Orthologous to human CNBD2 (cyclic nucleotide binding domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 14.9), spleen adult (RPKM 5.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cnbd2 in Genome Data Viewer
    Location:
    2 H1; 2 77.39 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (156153866..156217558)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156311946..156375638)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 39 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156005117-156005304 Neighboring gene STARR-positive B cell enhancer ABC_E817 Neighboring gene STARR-seq mESC enhancer starr_06156 Neighboring gene STARR-positive B cell enhancer ABC_E9537 Neighboring gene STARR-seq mESC enhancer starr_06157 Neighboring gene PHD finger protein 20 Neighboring gene STARR-seq mESC enhancer starr_06159 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156104477-156104678 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156113998-156114107 Neighboring gene SCAN domain-containing 1 Neighboring gene predicted gene 14251 Neighboring gene STARR-seq mESC enhancer starr_06163 Neighboring gene STARR-positive B cell enhancer mm9_chr2:156182424-156182725 Neighboring gene programmed cell death 10 pseudogene Neighboring gene predicted gene 14170 Neighboring gene ribosomal protein L21, pseudogene 9 Neighboring gene non-coding RNA activated by DNA damage

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CRIS-a novel cAMP-binding protein controlling spermiogenesis and the development of flagellar bending. Krähling AM, et al. PLoS Genet, 2013. PMID 24339785, Free PMC Article
    2. Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease. Tkatchenko TV, et al. Physiol Genomics, 2009 Nov 6. PMID 19723774, Free PMC Article
    3. Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each. Dogar AM, et al. PLoS One, 2018. PMID 30418981, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cAMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclic nucleotide-binding domain-containing protein 2
    Names
    cyclic nucleotide-receptor involved in sperm function

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316755.1 → NP_001303684.1  cyclic nucleotide-binding domain-containing protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 3' exon in place of the last four exons compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK162372, BY097898
      UniProtKB/TrEMBL
      Q3TRZ7
      Conserved Domains (2) summary
      COG0664
      Location:200 → 353
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:200 → 308
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    2. NM_027585.2 → NP_081861.2  cyclic nucleotide-binding domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_081861.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK014912, BX637137, BY097898
      Consensus CDS
      CCDS50778.1
      UniProtKB/Swiss-Prot
      A2ATV2, Q8R083, Q9D5U8
      UniProtKB/TrEMBL
      B2RU56, S4S403
      Related
      ENSMUSP00000041268.3, ENSMUST00000037096.9
      Conserved Domains (2) summary
      COG0664
      Location:200 → 353
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:211 → 308
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      156153866..156217558
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252071.2 → XP_030107931.1  cyclic nucleotide-binding domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      Q3TRZ7
      Conserved Domains (1) summary
      cd00038
      Location:165 → 262
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    2. XM_036162566.1 → XP_036018459.1  cyclic nucleotide-binding domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      B2RU56, S4S403
      Conserved Domains (1) summary
      cd00038
      Location:200 → 308
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    3. XM_006500172.5 → XP_006500235.1  cyclic nucleotide-binding domain-containing protein 2 isoform X5

      Conserved Domains (1) summary
      cd00038
      Location:211 → 308
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    4. XM_006500167.4 → XP_006500230.1  cyclic nucleotide-binding domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      B2RU56, S4S403
      Conserved Domains (1) summary
      cd00038
      Location:165 → 262
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    5. XM_036162567.1 → XP_036018460.1  cyclic nucleotide-binding domain-containing protein 2 isoform X3

      Conserved Domains (1) summary
      cd00038
      Location:154 → 262
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    RNA

    1. XR_003953718.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D5U8.2 GenPept UniProtKB/Swiss-Prot:Q9D5U8

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