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    Clec4g C-type lectin domain family 4, member g [ Mus musculus (house mouse) ]

    Gene ID: 75863, updated on 9-Dec-2024

    Summary

    Official Symbol
    Clec4gprovided by MGI
    Official Full Name
    C-type lectin domain family 4, member gprovided by MGI
    Primary source
    MGI:MGI:1923113
    See related
    Ensembl:ENSMUSG00000074491 AllianceGenome:MGI:1923113
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930572L20Rik
    Summary
    Enables polysaccharide binding activity. Acts upstream of or within negative regulation of T cell mediated immunity; negative regulation of alpha-beta T cell proliferation; and negative regulation of immature T cell proliferation in thymus. Located in plasma membrane. Orthologous to human CLEC4G (C-type lectin domain family 4 member G). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 8.6), testis adult (RPKM 6.3) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Clec4g in Genome Data Viewer
    Location:
    8 A1.1; 8 1.92 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (3757066..3770695, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (3707066..3720695, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 45231 Neighboring gene trafficking protein particle complex 5 Neighboring gene Fc receptor, IgE, low affinity II, alpha polypeptide Neighboring gene predicted gene 16553 Neighboring gene STARR-positive B cell enhancer mm9_chr8:3718569-3718869 Neighboring gene CD209a antigen Neighboring gene STARR-seq mESC enhancer starr_20597 Neighboring gene ribonuclease P RNA-like 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-mannose binding  
    enables D-mannose binding  
    enables carbohydrate binding  
    enables carbohydrate derivative binding  
    enables carbohydrate derivative binding  
    enables fructose binding  
    enables fructose binding  
    enables pattern recognition receptor activity  
    enables polysaccharide binding PubMed 
    enables protein binding PubMed 
    enables virus coreceptor activity  
    enables virus coreceptor activity  
    enables virus receptor activity  
    enables virus receptor activity  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  

    General protein information

    Preferred Names
    C-type lectin domain family 4 member G

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029465.3NP_083741.1  C-type lectin domain family 4 member G

      See identical proteins and their annotated locations for NP_083741.1

      Status: VALIDATED

      Source sequence(s)
      AI449163, AK079992
      Consensus CDS
      CCDS22072.1
      UniProtKB/Swiss-Prot
      Q5I0T7, Q8BNX1, Q8R188
      Related
      ENSMUSP00000059574.7, ENSMUST00000062037.7
      Conserved Domains (2) summary
      cl02432
      Location:165289
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      cl19764
      Location:61163
      COG6; Conserved oligomeric complex COG6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      3757066..3770695 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_870085.3 RNA Sequence

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