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    Rint1 RAD50 interactor 1 [ Mus musculus (house mouse) ]

    Gene ID: 72772, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rint1provided by MGI
    Official Full Name
    RAD50 interactor 1provided by MGI
    Primary source
    MGI:MGI:1916233
    See related
    Ensembl:ENSMUSG00000028999 AllianceGenome:MGI:1916233
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rint-1; 1500019C06Rik; 2810450M21Rik
    Summary
    Predicted to be involved in mitotic G2 DNA damage checkpoint signaling; regulation of ER to Golgi vesicle-mediated transport; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in endoplasmic reticulum. Predicted to be part of Dsl1/NZR complex. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in infantile liver failure syndrome. Orthologous to human RINT1 (RAD50 interactor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 6.8), limb E14.5 (RPKM 6.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rint1 in Genome Data Viewer
    Location:
    5 A3; 5 10.45 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (23992700..24028582)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (23787698..23823584)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene expressed sequence AI506816 Neighboring gene STARR-positive B cell enhancer ABC_E8818 Neighboring gene STARR-positive B cell enhancer ABC_E3564 Neighboring gene predicted gene, 50451 Neighboring gene pseudouridylate synthase 7 Neighboring gene STARR-seq mESC enhancer starr_12621 Neighboring gene STARR-positive B cell enhancer ABC_E4745 Neighboring gene RIKEN cDNA 4933427G23 gene Neighboring gene predicted gene, 22054

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RINT1 functions as a multitasking protein at the crossroads between genomic stability, ER homeostasis, and autophagy. Grigaravicius P, et al. Autophagy, 2016 Aug 2. PMID 27367497, Free PMC Article
    2. RINT-1 serves as a tumor suppressor and maintains Golgi dynamics and centrosome integrity for cell survival. Lin X, et al. Mol Cell Biol, 2007 Jul. PMID 17470549, Free PMC Article
    3. Evaluation of Rint1 as a modifier of intestinal tumorigenesis and cancer risk. Otterpohl KL, et al. PLoS One, 2017. PMID 28264000, Free PMC Article
    4. Genetic mapping of Mom5, a novel modifier of Apc(Min)-induced intestinal tumorigenesis. Oikarinen SI, et al. Carcinogenesis, 2009 Sep. PMID 19574546
    5. RINT1 Loss Impairs Retinogenesis Through TRP53-Mediated Apoptosis. Gomes AL, et al. Front Cell Dev Biol, 2020. PMID 32850831, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RINT1 has a role as a multitasking protein with roles in genomic stability, ER homeostasis, and autophagy
      Title: RINT1 functions as a multitasking protein at the crossroads between genomic stability, ER homeostasis, and autophagy.
    2. these data are more consistent with the hypothesis that RINT1 functions as an oncogene rather than a tumor suppressor gene in the context of colorectal cancer.
      Title: Evaluation of Rint1 as a modifier of intestinal tumorigenesis and cancer risk.
    3. A crucial role of Rint1 in vivo in genomic stability maintenance, as well as in prevention of endoplasmic reticulum stress and autophagy.
      Title: Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain.
    4. These findings suggest that RINT-1 serves as a novel tumor suppressor essential for maintaining the dynamic integrity of the Golgi apparatus and the centrosome, a prerequisite to their proper coordination during cell division.
      Title: RINT-1 serves as a tumor suppressor and maintains Golgi dynamics and centrosome integrity for cell survival.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC183656

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of ER to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of ER to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of ER to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Dsl1/NZR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Dsl1/NZR complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Dsl1/NZR complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RAD50-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310467.1 → NP_001297396.1  RAD50-interacting protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001297396.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK005284, AK028707, BC065059
      Consensus CDS
      CCDS80220.1
      UniProtKB/TrEMBL
      B2RWX4
      Related
      ENSMUSP00000110766.3, ENSMUST00000115113.3
      Conserved Domains (1) summary
      pfam04437
      Location:246 → 726
      RINT1_TIP1; RINT-1 / TIP-1 family

    2. NM_177323.4 → NP_796297.2  RAD50-interacting protein 1 isoform 1

      See identical proteins and their annotated locations for NP_796297.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK005284, AK135334, BC065059
      Consensus CDS
      CCDS39025.1
      UniProtKB/Swiss-Prot
      Q3UXS1, Q6P1I2, Q8BZ36, Q8C193
      UniProtKB/TrEMBL
      B2RWX4
      Related
      ENSMUSP00000030852.7, ENSMUST00000030852.13
      Conserved Domains (1) summary
      pfam04437
      Location:304 → 784
      RINT1_TIP1; RINT-1 / TIP-1 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      23992700..24028582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165534.1 → XP_036021427.1  RAD50-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      B2RWX4
      Conserved Domains (1) summary
      pfam04437
      Location:168 → 648
      RINT1_TIP1; RINT-1 / TIP-1 family

    RNA

    1. XR_001784750.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BZ36.2 GenPept UniProtKB/Swiss-Prot:Q8BZ36

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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