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    Eif5a2 eukaryotic translation initiation factor 5A2 [ Mus musculus (house mouse) ]

    Gene ID: 208691, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eif5a2provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 5A2provided by MGI
    Primary source
    MGI:MGI:1933735
    See related
    Ensembl:ENSMUSG00000050192 AllianceGenome:MGI:1933735
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    eIF5AII; 9630038B20
    Summary
    Predicted to enable translation elongation factor activity. Predicted to be involved in translational elongation. Predicted to be located in intracellular membrane-bounded organelle. Orthologous to human EIF5A2 (eukaryotic translation initiation factor 5A2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 10.7), cortex adult (RPKM 6.2) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eif5a2 in Genome Data Viewer
    Location:
    3 A3; 3 12.25 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (28835426..28852995)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (28781032..28798846)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700112D23 gene Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 2 Neighboring gene predicted pseudogene 6505 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:28679958-28680067 Neighboring gene predicted gene, 32950 Neighboring gene STARR-positive B cell enhancer ABC_E6046 Neighboring gene ribosomal protein L22 like 1 Neighboring gene predicted gene, 33051

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A Translational Regulatory Mechanism Mediated by Hypusinated Eukaryotic Initiation Factor 5A Facilitates β-Cell Identity and Function. Connors CT, et al. Diabetes, 2024 Mar 1. PMID 38055903, Free PMC Article
    2. Eukaryotic initiation factor 5A2 mediates hypoxia-induced autophagy and cisplatin resistance. Xu G, et al. Cell Death Dis, 2022 Aug 5. PMID 35931669, Free PMC Article
    3. New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape. Schultz CR, et al. Biol Open, 2023 Mar 15. PMID 36848144, Free PMC Article
    4. Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability. Chen M, et al. BMC Cancer, 2011 May 26. PMID 21612665, Free PMC Article
    5. Mutation at the Evi1 locus in Junbo mice causes susceptibility to otitis media. Parkinson N, et al. PLoS Genet, 2006 Oct 6. PMID 17029558, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. microRNA-15a-5p suppresses hypoxia-induced tumor growth and chemoresistance in bladder cancer by binding to eIF5A2.
      Title: microRNA-15a-5p suppresses hypoxia-induced tumor growth and chemoresistance in bladder cancer by binding to eIF5A2.
    2. A Translational Regulatory Mechanism Mediated by Hypusinated Eukaryotic Initiation Factor 5A Facilitates beta-Cell Identity and Function.
      Title: A Translational Regulatory Mechanism Mediated by Hypusinated Eukaryotic Initiation Factor 5A Facilitates β-Cell Identity and Function.
    3. New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape.
      Title: New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape.
    4. Eukaryotic initiation factor 5A2 mediates hypoxia-induced autophagy and cisplatin resistance.
      Title: Eukaryotic initiation factor 5A2 mediates hypoxia-induced autophagy and cisplatin resistance.
    5. activation of eIF-5A2 repressed p19 level and therefore destabilized p53 in transgenic mouse embryo fibroblast (MEF) cells. This subsequently allowed for the accumulation of chromosomal instability.
      Title: Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability.
    6. Eukaryotic initiation factor 5A (eIF5A) (eIF-4D, eIF-5A) stimulates ribosomal peptidyltransferase activity, transport of HIV-1-mRNAs and binds exportins 1 and 4. Contains hypusine at lys 50. Mouse EIF5A1 and EIF5A2 encode two isoforms: eIF5AI and eIF5AII.
      Title: Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124092, MGC124093

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of translational termination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 5A-2
    Names
    eukaryotic initiation factor 5A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177586.6 → NP_808254.1  eukaryotic translation initiation factor 5A-2

      See identical proteins and their annotated locations for NP_808254.1

      Status: VALIDATED

      Source sequence(s)
      AC122490
      Consensus CDS
      CCDS17277.1
      UniProtKB/Swiss-Prot
      Q8BGY2
      Related
      ENSMUSP00000050289.8, ENSMUST00000060500.9
      Conserved Domains (1) summary
      cl30809
      Location:1 → 150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      28835426..28852995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGY2.3 GenPept UniProtKB/Swiss-Prot:Q8BGY2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
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