Tshz3 teashirt zinc finger family member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tshz3provided by MGI
Official Full Name: teashirt zinc finger family member 3provided by MGI
Primary source: MGI:MGI:2442819
See related: Ensembl:ENSMUSG00000021217 AllianceGenome:MGI:2442819
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tsh3; Zfp537; mKIAA1474; teashirt3; A630038G13Rik
Summary: Predicted to enable DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and chromatin binding activity. Involved in several processes, including positive regulation of synaptic transmission; regulation of respiratory gaseous exchange by nervous system process; and smooth muscle tissue development. Acts upstream of or within several processes, including kidney development; positive regulation of smooth muscle cell differentiation; and sensory perception of touch. Located in mitochondrion. Is expressed in genitourinary system and peripheral nervous system. Used to study autism spectrum disorder. Orthologous to human TSHZ3 (teashirt zinc finger homeobox 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bladder adult (RPKM 8.7), whole brain E14.5 (RPKM 6.9) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B2; 7 22.79 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (36397543..36472978)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (36698118..36773553)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Haploinsufficiency of the mouse Tshz3 gene leads to kidney defects.
Title: Haploinsufficiency of the mouse Tshz3 gene leads to kidney defects.
The study conditional Tshz3 knockout mouse constitutes a novel autism spectrum disorder model, opening the possibility for an early postnatal therapeutic window for the syndrome linked to TSHZ3 haploinsufficiency.
Title: Postnatal Tshz3 Deletion Drives Altered Corticostriatal Function and Autism Spectrum Disorder-like Behavior.
strong experimental evidence for a causal relationship between Tshz3 heterozygosity, functional defaults in cortical projection neurons, and autism spectrum disorder
Title: TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons.
suggest a novel mechanism for transcriptional repression by TSHZ3 in which TSHZ3 and BAF57 cooperate to modulate MyoD activity on the Myog promoter to regulate skeletal muscle differentiation.
Title: Teashirt-3, a novel regulator of muscle differentiation, associates with BRG1-associated factor 57 (BAF57) to inhibit myogenin gene expression.
Thus, a single gene, Tshz3, controls the development of diverse components of the circuitry required for breathing.
Title: Teashirt 3 regulates development of neurons involved in both respiratory rhythm and airflow control.
Mice that are null mutant for the Teashirt3 (Tshz3) gene exhibit congenital pelvi-ureteric junction obstruction with defective smooth muscle differentiation and absent peristalsis in the proximal ureter.
Title: Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction.
ureteric smooth muscle cell precursors express the transcription factor teashirt 3 (TSHZ3), and Tshz3-null mutants have congenital hydronephrosis without anatomical obstruction
Title: Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4.
role for mTsh genes in the establishment of regional identity and specification of cell types in the developing and adult forebrain
Title: Expression patterns of the three Teashirt-related genes define specific boundaries in the developing and postnatal mouse forebrain.
three mouse Tsh genes are functionally equivalent to the Drosophila tsh gene when expressed in developing Drosophila embryos
Title: Three putative murine Teashirt orthologues specify trunk structures in Drosophila in the same way as the Drosophila teashirt gene.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH99014 (e-PCR)
- UniSTS:91398

RH46365 (e-PCR)
- UniSTS:75091

RH137184 (e-PCR)
- UniSTS:219272

TSHZ3 (e-PCR)
- UniSTS:504460

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within kidney morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in kidney smooth muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lung development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metanephros development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within musculoskeletal movement	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of smooth muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of respiratory gaseous exchange by nervous system process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception of touch	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within smooth muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ureter smooth muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ureteric bud development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ureteric peristalsis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: teashirt homolog 3

Names: teashirt 3; zinc finger protein 537

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172298.3 → NP_758502.1 teashirt homolog 3

See identical proteins and their annotated locations for NP_758502.1

Status: VALIDATED

Source sequence(s)

AC129593, AI413240

Consensus CDS

CCDS39913.1

UniProtKB/Swiss-Prot

Q5DTX4, Q8CGV9

UniProtKB/TrEMBL

A0A0R4J017

Related

ENSMUSP00000021641.7, ENSMUST00000021641.8

Conserved Domains (2) summary

cd00086
Location:892 → 960

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00020
Location:216 → 238

ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

36397543..36472978

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539964.4 → XP_006540027.1 teashirt homolog 3 isoform X3

See identical proteins and their annotated locations for XP_006540027.1

UniProtKB/Swiss-Prot

Q5DTX4, Q8CGV9

Conserved Domains (2) summary

cd00086
Location:903 → 971

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00020
Location:227 → 249

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_017322238.3 → XP_017177727.1 teashirt homolog 3 isoform X4

UniProtKB/Swiss-Prot

Q5DTX4, Q8CGV9

Conserved Domains (2) summary

cd00086
Location:847 → 915

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00020
Location:171 → 193

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_006539965.3 → XP_006540028.2 teashirt homolog 3 isoform X1

UniProtKB/Swiss-Prot

Q5DTX4, Q8CGV9

Conserved Domains (3) summary

cd00086
Location:1014 → 1082

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00020
Location:338 → 360

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12874
Location:1163 → 1186

zf-met; Zinc-finger of C2H2 type
XM_006539963.1 → XP_006540026.1 teashirt homolog 3 isoform X3

See identical proteins and their annotated locations for XP_006540026.1

UniProtKB/Swiss-Prot

Q5DTX4, Q8CGV9

Conserved Domains (2) summary

cd00086
Location:903 → 971

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00020
Location:227 → 249

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_006539966.5 → XP_006540029.1 teashirt homolog 3 isoform X4

See identical proteins and their annotated locations for XP_006540029.1

UniProtKB/Swiss-Prot

Q5DTX4, Q8CGV9

Conserved Domains (2) summary

cd00086
Location:847 → 915

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00020
Location:171 → 193

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_006539961.4 → XP_006540024.1 teashirt homolog 3 isoform X2

UniProtKB/Swiss-Prot

Q5DTX4, Q8CGV9

Conserved Domains (2) summary

cd00086
Location:936 → 1004

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00020
Location:260 → 282

ZF_C2H2; C2H2 Zn finger [structural motif]