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    Lhx4 LIM homeobox protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 16872, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lhx4provided by MGI
    Official Full Name
    LIM homeobox protein 4provided by MGI
    Primary source
    MGI:MGI:101776
    See related
    Ensembl:ENSMUSG00000026468 AllianceGenome:MGI:101776
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gsh4; Gsh-4; A330062J17Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and methyl-CpG binding activity. Acts upstream of or within several processes, including negative regulation of apoptotic process; neuron differentiation; and placenta development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in panhypopituitarism. Orthologous to human LHX4 (LIM homeobox 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See Lhx4 in Genome Data Viewer
    Location:
    1 G3; 1 67.47 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (155573777..155627481, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (155698031..155751726, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5532 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:157405138-157405321 Neighboring gene STARR-positive B cell enhancer ABC_E9484 Neighboring gene STARR-positive B cell enhancer mm9_chr1:157423836-157424136 Neighboring gene acyl-Coenzyme A binding domain containing 6 Neighboring gene STARR-seq mESC enhancer starr_02727 Neighboring gene STARR-positive B cell enhancer mm9_chr1:157659814-157660115 Neighboring gene quiescin Q6 sulfhydryl oxidase 1 Neighboring gene centrosomal protein 350 Neighboring gene predicted gene, 36934

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in intracellular anatomical structure PubMed 
    located_in nucleoplasm  
    is_active_in nucleus  

    General protein information

    Preferred Names
    LIM/homeobox protein Lhx4
    Names
    LIM homeo box protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010712.2NP_034842.2  LIM/homeobox protein Lhx4

      See identical proteins and their annotated locations for NP_034842.2

      Status: VALIDATED

      Source sequence(s)
      AC117598, BC049834
      Consensus CDS
      CCDS48399.1
      UniProtKB/Swiss-Prot
      O08916, P53776, Q810K7, Q9R280
      Related
      ENSMUSP00000027740.8, ENSMUST00000027740.14
      Conserved Domains (3) summary
      cd09376
      Location:89144
      LIM2_Lhx3_Lhx4; The second LIM domain of Lhx3-Lhx4 family
      cd09468
      Location:3081
      LIM1_Lhx4; The first LIM domain of Lhx4
      pfam00046
      Location:160213
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      155573777..155627481 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529169.3XP_006529232.1  LIM/homeobox protein Lhx4 isoform X1

      See identical proteins and their annotated locations for XP_006529232.1

      Conserved Domains (3) summary
      cd09376
      Location:2883
      LIM2_Lhx3_Lhx4; The second LIM domain of Lhx3-Lhx4 family
      cl02475
      Location:120
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam00046
      Location:99153
      Homeobox; Homeobox domain
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