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    Thsd7b thrombospondin, type I, domain containing 7B [ Mus musculus (house mouse) ]

    Gene ID: 210417, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Thsd7bprovided by MGI
    Official Full Name
    thrombospondin, type I, domain containing 7Bprovided by MGI
    Primary source
    MGI:MGI:2443925
    See related
    Ensembl:ENSMUSG00000042581 AllianceGenome:MGI:2443925
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B930082A18; 1700074E13Rik; D130067I03Rik
    Summary
    Predicted to be involved in actin cytoskeleton organization. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in embryo. Orthologous to human THSD7B (thrombospondin type 1 domain containing 7B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Thsd7b in Genome Data Viewer
    Location:
    1 E4; 1 56.55 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (129201010..130147015)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (129273190..130219278)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:130487786-130488065 Neighboring gene STARR-positive B cell enhancer ABC_E10032 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:130502453-130502636 Neighboring gene STARR-positive B cell enhancer ABC_E4345 Neighboring gene STARR-positive B cell enhancer ABC_E10033 Neighboring gene STARR-positive B cell enhancer ABC_E7744 Neighboring gene C-X-C motif chemokine receptor 4 Neighboring gene STARR-seq mESC enhancer starr_02173 Neighboring gene STARR-positive B cell enhancer ABC_E9477 Neighboring gene STARR-seq mESC enhancer starr_02174 Neighboring gene STARR-positive B cell enhancer ABC_E2007 Neighboring gene STARR-seq mESC enhancer starr_02175 Neighboring gene STARR-seq mESC enhancer starr_02176 Neighboring gene STARR-seq mESC enhancer starr_02178 Neighboring gene STARR-seq mESC enhancer starr_02179 Neighboring gene predicted gene, 23056 Neighboring gene STARR-seq mESC enhancer starr_02180 Neighboring gene STARR-seq mESC enhancer starr_02181 Neighboring gene STARR-seq mESC enhancer starr_02182 Neighboring gene STARR-seq mESC enhancer starr_02183 Neighboring gene STARR-seq mESC enhancer starr_02184 Neighboring gene STARR-seq mESC enhancer starr_02185 Neighboring gene STARR-seq mESC enhancer starr_02186 Neighboring gene predicted gene, 36347 Neighboring gene STARR-seq mESC enhancer starr_02187 Neighboring gene ribosomal protein L31, pseudogene 9 Neighboring gene nucleoporin 54 pseudogene Neighboring gene STARR-seq mESC enhancer starr_02188 Neighboring gene STARR-seq mESC enhancer starr_02189 Neighboring gene STARR-seq mESC enhancer starr_02190 Neighboring gene STARR-seq mESC enhancer starr_02191 Neighboring gene STARR-seq mESC enhancer starr_02192 Neighboring gene predicted gene 29428 Neighboring gene STARR-seq mESC enhancer starr_02193 Neighboring gene STARR-seq mESC enhancer starr_02194 Neighboring gene predicted gene, 41951 Neighboring gene CD55 molecule, opposite strand sequence Neighboring gene CD55 molecule, decay accelerating factor for complement B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Exercise-augmented THSD7B exhibited a positive prognostic implication and tumor-suppressed functionality in pan-cancer. Luo Z, et al. Front Immunol, 2024. PMID 39161765, Free PMC Article
    2. O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Du J, et al. Dev Biol, 2010 Oct 1. PMID 20637190, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exercise-augmented THSD7B exhibited a positive prognostic implication and tumor-suppressed functionality in pan-cancer.
      Title: Exercise-augmented THSD7B exhibited a positive prognostic implication and tumor-suppressed functionality in pan-cancer.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    thrombospondin type-1 domain-containing protein 7B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172485.3 → NP_766073.2  thrombospondin type-1 domain-containing protein 7B precursor

      See identical proteins and their annotated locations for NP_766073.2

      Status: VALIDATED

      Source sequence(s)
      AC110536, BB658510, BC063250
      Consensus CDS
      CCDS15255.1
      UniProtKB/Swiss-Prot
      Q6P4U0
      Related
      ENSMUSP00000073220.7, ENSMUST00000073527.13
      Conserved Domains (2) summary
      smart00209
      Location:1252 → 1302
      TSP1; Thrombospondin type 1 repeats
      cl15278
      Location:1132 → 1177
      TSP_1; Thrombospondin type 1 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      129201010..130147015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247964.3 → XP_011246266.1  thrombospondin type-1 domain-containing protein 7B isoform X1

      See identical proteins and their annotated locations for XP_011246266.1

      Conserved Domains (2) summary
      pfam19028
      Location:337 → 398
      TSP1_spondin; Spondin-like TSP1 domain
      pfam19030
      Location:1065 → 1125
      TSP1_ADAMTS; Thrombospondin type 1 domain

    2. XM_011247966.4 → XP_011246268.1  thrombospondin type-1 domain-containing protein 7B isoform X2

      Conserved Domains (1) summary
      smart00209
      Location:340 → 399
      TSP1; Thrombospondin type 1 repeats

    3. XM_036163210.1 → XP_036019103.1  thrombospondin type-1 domain-containing protein 7B isoform X1

      Conserved Domains (2) summary
      pfam19028
      Location:337 → 398
      TSP1_spondin; Spondin-like TSP1 domain
      pfam19030
      Location:1065 → 1125
      TSP1_ADAMTS; Thrombospondin type 1 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P4U0.1 GenPept UniProtKB/Swiss-Prot:Q6P4U0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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