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    Ocln occludin [ Mus musculus (house mouse) ]

    Gene ID: 18260, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Oclnprovided by MGI
    Official Full Name
    occludinprovided by MGI
    Primary source
    MGI:MGI:106183
    See related
    Ensembl:ENSMUSG00000021638 AllianceGenome:MGI:106183
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ocl
    Summary
    Predicted to enable protein domain specific binding activity. Involved in negative regulation of gene expression and tight junction organization. Located in several cellular components, including apical plasma membrane; apicolateral plasma membrane; and bicellular tight junction. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Crohn's disease and pseudo-TORCH syndrome 1. Orthologous to human OCLN (occludin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in large intestine adult (RPKM 9.2), colon adult (RPKM 5.6) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ocln in Genome Data Viewer
    Location:
    13 D1; 13 53.23 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100633012..100689226, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100496504..100552718, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31, pseudogene 13 Neighboring gene NLR family, apoptosis inhibitory protein 1 Neighboring gene general transcription factor II H, polypeptide 2 Neighboring gene STARR-positive B cell enhancer ABC_E1467 Neighboring gene predicted gene, 57598 Neighboring gene eukaryotic translation initiation factor 4, gamma 1 pseudogene Neighboring gene MARVEL (membrane-associating) domain containing 2 Neighboring gene predicted gene, 24261

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Occludin is a target of Src kinase and promotes lipid secretion by binding to BTN1a1 and XOR. Lu Y, et al. PLoS Biol, 2022 Jan. PMID 35041644, Free PMC Article
    2. Disruption of occludin function in polarized epithelial cells activates the extrinsic pathway of apoptosis leading to cell extrusion without loss of transepithelial resistance. Beeman NE, et al. BMC Cell Biol, 2009 Dec 9. PMID 20003227, Free PMC Article
    3. Occludin deficiency promotes ethanol-induced disruption of colonic epithelial junctions, gut barrier dysfunction and liver damage in mice. Mir H, et al. Biochim Biophys Acta, 2016 Apr. PMID 26721332, Free PMC Article
    4. The oligomerization of the coiled coil-domain of occludin is redox sensitive. Walter JK, et al. Ann N Y Acad Sci, 2009 May. PMID 19538283
    5. Occludin protects secretory cells from ER stress by facilitating SNARE-dependent apical protein exocytosis. Zhou T, et al. Proc Natl Acad Sci U S A, 2020 Mar 3. PMID 32051248, Free PMC Article

    See all (217) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA SNHG5/IGF2BP1/Occludin axis regulates Nd2O3 induced blood-testis barrier disruption.
      Title: LncRNA SNHG5/IGF2BP1/Occludin axis regulates Nd(2)O(3) induced blood-testis barrier disruption.
    2. Low temperature reduces occludin expression in bronchial epithelial cells: Implications in cold-induced asthma.
      Title: Low temperature reduces occludin expression in bronchial epithelial cells: Implications in cold-induced asthma.
    3. Autophagy Reduces the Degradation and Promotes Membrane Localization of Occludin to Enhance the Intestinal Epithelial Tight Junction Barrier against Paracellular Macromolecule Flux.
      Title: Autophagy Reduces the Degradation and Promotes Membrane Localization of Occludin to Enhance the Intestinal Epithelial Tight Junction Barrier against Paracellular Macromolecule Flux.
    4. The tight junction protein occludin modulates blood-brain barrier integrity and neurological function after ischemic stroke in mice.
      Title: The tight junction protein occludin modulates blood-brain barrier integrity and neurological function after ischemic stroke in mice.
    5. Prenatal arsenic exposure stymies gut butyrate production and enhances gut permeability in post natal life even in absence of arsenic deftly through miR122-Occludin pathway.
      Title: Prenatal arsenic exposure stymies gut butyrate production and enhances gut permeability in post natal life even in absence of arsenic deftly through miR122-Occludin pathway.
    6. Epididymal epithelial degeneration and lipid metabolism impairment account for male infertility in occludin knockout mice.
      Title: Epididymal epithelial degeneration and lipid metabolism impairment account for male infertility in occludin knockout mice.
    7. Occludin facilitates tumour angiogenesis in bladder cancer by regulating IL8/STAT3 through STAT4.
      Title: Occludin facilitates tumour angiogenesis in bladder cancer by regulating IL8/STAT3 through STAT4.
    8. The mRNA-binding protein IGF2BP1 maintains intestinal barrier function by up-regulating occludin expression.
      Title: The mRNA-binding protein IGF2BP1 maintains intestinal barrier function by up-regulating occludin expression.
    9. Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles.
      Title: Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles.
    10. The tight junction protein occludin regulates apoptosis by enhancing caspase-3 transcription in intestinal epithelial cells.
      Title: Inflammation-induced Occludin Downregulation Limits Epithelial Apoptosis by Suppressing Caspase-3 Expression.
    Submit: New GeneRIF Correction See all GeneRIFs (52)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in bicellular tight junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bicellular tight junction assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell-cell junction organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of D-glucose import IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of D-glucose import ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of blood-brain barrier permeability IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of blood-brain barrier permeability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of D-glucose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to interleukin-18 ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tight junction organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apicolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in tight junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    occludin
    NP_001347465.1
    NP_001347466.1
    NP_001347467.1
    NP_001347468.1
    NP_032782.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360536.1 → NP_001347465.1  occludin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC158536
      Consensus CDS
      CCDS26731.1
      UniProtKB/Swiss-Prot
      Q544A7, Q61146
      UniProtKB/TrEMBL
      B2RS24
      Related
      ENSMUSP00000022140.6, ENSMUST00000022140.12
      Conserved Domains (2) summary
      pfam01284
      Location:57 → 261
      MARVEL; Membrane-associating domain
      pfam07303
      Location:419 → 518
      Occludin_ELL; Occludin homology domain

    2. NM_001360537.1 → NP_001347466.1  occludin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC158536
      Consensus CDS
      CCDS26731.1
      UniProtKB/Swiss-Prot
      Q544A7, Q61146
      UniProtKB/TrEMBL
      B2RS24
      Related
      ENSMUSP00000124849.2, ENSMUST00000160859.8
      Conserved Domains (2) summary
      pfam01284
      Location:57 → 261
      MARVEL; Membrane-associating domain
      pfam07303
      Location:419 → 518
      Occludin_ELL; Occludin homology domain

    3. NM_001360538.1 → NP_001347467.1  occludin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC158536
      Consensus CDS
      CCDS26731.1
      UniProtKB/Swiss-Prot
      Q544A7, Q61146
      UniProtKB/TrEMBL
      B2RS24
      Conserved Domains (2) summary
      pfam01284
      Location:57 → 261
      MARVEL; Membrane-associating domain
      pfam07303
      Location:419 → 518
      Occludin_ELL; Occludin homology domain

    4. NM_001360539.1 → NP_001347468.1  occludin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158536
      UniProtKB/TrEMBL
      Q3UKZ5
      Related
      ENSMUSP00000125642.2, ENSMUST00000159459.8
      Conserved Domains (1) summary
      pfam07303
      Location:225 → 324
      Occludin_ELL; Occludin homology domain

    5. NM_008756.2 → NP_032782.1  occludin isoform 1

      See identical proteins and their annotated locations for NP_032782.1

      Status: VALIDATED

      Source sequence(s)
      AK042576
      Consensus CDS
      CCDS26731.1
      UniProtKB/Swiss-Prot
      Q544A7, Q61146
      UniProtKB/TrEMBL
      B2RS24
      Related
      ENSMUSP00000065284.5, ENSMUST00000069756.11
      Conserved Domains (2) summary
      pfam01284
      Location:57 → 261
      MARVEL; Membrane-associating domain
      pfam07303
      Location:419 → 518
      Occludin_ELL; Occludin homology domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      100633012..100689226 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61146.1 GenPept UniProtKB/Swiss-Prot:Q61146

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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