Mndal myeloid nuclear differentiation antigen like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mndalprovided by MGI
Official Full Name: myeloid nuclear differentiation antigen likeprovided by MGI
Primary source: MGI:MGI:3780953
See related: Ensembl:ENSMUSG00000090272 AllianceGenome:MGI:3780953
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm2785; Ifi212
Summary: Predicted to enable double-stranded DNA binding activity and identical protein binding activity. Involved in negative regulation of cell growth. Located in nucleus. Is expressed in central nervous system and retina. Orthologous to human IFI16 (interferon gamma inducible protein 16). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bladder adult (RPKM 3.3), spleen adult (RPKM 2.7) and 18 other tissues See more
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Genomic context

Location:: 1 H3; 1 80.71 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (173684786..173708038, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (173857215..173880382, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mndal acts as a tumor suppressor and displays haploinsufficiency
Title: Mndal, a new interferon-inducible family member, is highly polymorphic, suppresses cell growth, and may modify plasmacytoma susceptibility.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Markers

Mnda (e-PCR), detects polymorphism
- UniSTS:547266

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables transcription factor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in activation of innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in activation of innate immune response	IEA Inferred from Electronic Annotation more info
involved_in activation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interferon-beta	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to interferon-beta	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ionizing radiation	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in monocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of AIM2 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA binding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression, epigenetic	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myeloid cell nuclear differentiation antigen-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170853.1 → NP_001164324.1 myeloid cell nuclear differentiation antigen-like protein isoform 1

See identical proteins and their annotated locations for NP_001164324.1

Status: VALIDATED

Source sequence(s)

AK136391, FJ594740

Consensus CDS

CCDS48452.1

UniProtKB/Swiss-Prot

D0QMC3, D0QMC4

UniProtKB/TrEMBL

A0A1Z3MHX2

Related

ENSMUSP00000140610.2, ENSMUST00000188804.7

Conserved Domains (2) summary

cd08305
Location:9 → 82

Pyrin; a protein-protein interaction domain

pfam02760
Location:311 → 479

HIN; HIN-200/IF120x domain
NM_001374640.1 → NP_001361569.1 myeloid cell nuclear differentiation antigen-like protein isoform 2

Status: VALIDATED

Source sequence(s)

AC170584

Consensus CDS

CCDS87927.1

UniProtKB/TrEMBL

A0A087WRA4

Related

ENSMUSP00000140539.2, ENSMUST00000186442.7

Conserved Domains (2) summary

cd08305
Location:9 → 82

Pyrin; a protein-protein interaction domain

pfam02760
Location:258 → 426

HIN; HIN-200/IF120x domain
NM_001400321.1 → NP_001387250.1 myeloid cell nuclear differentiation antigen-like protein isoform 1

Status: VALIDATED

Source sequence(s)

AC170584

UniProtKB/Swiss-Prot

D0QMC3, D0QMC4

UniProtKB/TrEMBL

A0A1Z3MHX2
NM_001400322.1 → NP_001387251.1 myeloid cell nuclear differentiation antigen-like protein isoform 1

Status: VALIDATED

Source sequence(s)

AC170584

UniProtKB/Swiss-Prot

D0QMC3, D0QMC4

UniProtKB/TrEMBL

A0A1Z3MHX2
NM_001400323.1 → NP_001387252.1 myeloid cell nuclear differentiation antigen-like protein isoform 3

Status: VALIDATED

Source sequence(s)

AC170584

UniProtKB/TrEMBL

A0A1Z3MHX2

RNA

NR_174474.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC170584
NR_174475.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC170584

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

173684786..173708038 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165678.1 → XP_036021571.1 myeloid cell nuclear differentiation antigen-like protein isoform X1

UniProtKB/Swiss-Prot

D0QMC3, D0QMC4

UniProtKB/TrEMBL

A0A1Z3MHX2

Conserved Domains (2) summary

cd08305
Location:9 → 82

Pyrin; a protein-protein interaction domain

pfam02760
Location:311 → 479

HIN; HIN-200/IF120x domain
XM_036165719.1 → XP_036021612.1 myeloid cell nuclear differentiation antigen-like protein isoform X1

UniProtKB/Swiss-Prot

D0QMC3, D0QMC4

UniProtKB/TrEMBL

A0A1Z3MHX2

Conserved Domains (2) summary

cd08305
Location:9 → 82

Pyrin; a protein-protein interaction domain

pfam02760
Location:311 → 479

HIN; HIN-200/IF120x domain
XM_036166134.1 → XP_036022027.1 myeloid cell nuclear differentiation antigen-like protein isoform X4

Conserved Domains (1) summary

pfam02760
Location:188 → 356

HIN; HIN-200/IF120x domain
XM_036152286.1 → XP_036008179.1 myeloid cell nuclear differentiation antigen-like protein isoform X5

Conserved Domains (1) summary

pfam02760
Location:132 → 300

HIN; HIN-200/IF120x domain
XM_036166009.1 → XP_036021902.1 myeloid cell nuclear differentiation antigen-like protein isoform X3

UniProtKB/TrEMBL

A0A087WRA4

Conserved Domains (2) summary

cd08305
Location:9 → 82

Pyrin; a protein-protein interaction domain

pfam02760
Location:258 → 426

HIN; HIN-200/IF120x domain
XM_036165861.1 → XP_036021754.1 myeloid cell nuclear differentiation antigen-like protein isoform X2

UniProtKB/TrEMBL

A0A1Z3MHX2

Conserved Domains (2) summary

cd08305
Location:9 → 82

Pyrin; a protein-protein interaction domain

pfam02760
Location:311 → 479

HIN; HIN-200/IF120x domain
XM_036152235.1 → XP_036008128.1 myeloid cell nuclear differentiation antigen-like protein isoform X4

Conserved Domains (1) summary

pfam02760
Location:188 → 356

HIN; HIN-200/IF120x domain
XM_036165636.1 → XP_036021529.1 myeloid cell nuclear differentiation antigen-like protein isoform X1

UniProtKB/Swiss-Prot

D0QMC3, D0QMC4

UniProtKB/TrEMBL

A0A1Z3MHX2

Conserved Domains (2) summary

cd08305
Location:9 → 82

Pyrin; a protein-protein interaction domain

pfam02760
Location:311 → 479

HIN; HIN-200/IF120x domain