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    Gnb1 G protein subunit beta 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24400, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gnb1provided by RGD
    Official Full Name
    G protein subunit beta 1provided by RGD
    Primary source
    RGD:2718
    See related
    EnsemblRapid:ENSRNOG00000016638 AllianceGenome:RGD:2718
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables alkylglycerophosphoethanolamine phosphodiesterase activity and spectrin binding activity. Involved in G protein-coupled receptor signaling pathway and positive regulation of cytosolic calcium ion concentration. Acts upstream of or within cardiac muscle cell apoptotic process and cellular response to hypoxia. Located in several cellular components, including cell body; photoreceptor inner segment; and photoreceptor outer segment membrane. Part of heterotrimeric G-protein complex. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; autosomal dominant intellectual developmental disorder 42; congestive heart failure; and myelodysplastic syndrome. Orthologous to human GNB1 (G protein subunit beta 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 1154.7), Lung (RPKM 759.7) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gnb1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171357778..171424489)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166075508..166142223)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (172914025..172981403)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 74 Neighboring gene transmembrane protein 52 Neighboring gene uncharacterized LOC120103052 Neighboring gene NAD kinase Neighboring gene ATP synthase peripheral stalk subunit d, pseudogene 1 Neighboring gene uncharacterized LOC134487048

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables alkylglycerophosphoethanolamine phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor complex adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables spectrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of heterotrimeric G-protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of heterotrimeric G-protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of heterotrimeric G-protein complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in photoreceptor inner segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in photoreceptor outer segment membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Names
    Guanine nucleotide-binding protein beta 1
    guanine nucleotide binding protein (G protein), beta 1
    guanine nucleotide binding protein (G protein), beta polypeptide 1
    guanine nucleotide binding protein, beta 1
    guanine nucleotide-binding protein, beta-1 subunit
    transducin beta chain 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430056.1NP_001416985.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P54311, Q6Q8B1, Q9QWG8
      UniProtKB/TrEMBL
      A6IUQ6
    2. NM_001430057.1NP_001416986.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P54311, Q6Q8B1, Q9QWG8
      UniProtKB/TrEMBL
      A6IUQ6
    3. NM_001430058.1NP_001416987.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P54311, Q6Q8B1, Q9QWG8
      UniProtKB/TrEMBL
      A6IUQ6
    4. NM_001430059.1NP_001416988.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P54311, Q6Q8B1, Q9QWG8
      UniProtKB/TrEMBL
      A6IUQ6
    5. NM_001430060.1NP_001416989.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P54311, Q6Q8B1, Q9QWG8
      UniProtKB/TrEMBL
      A6IUQ6
    6. NM_001430061.1NP_001416990.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P54311, Q6Q8B1, Q9QWG8
      UniProtKB/TrEMBL
      A6IUQ6
    7. NM_001430062.1NP_001416991.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P54311, Q6Q8B1, Q9QWG8
      UniProtKB/TrEMBL
      A6IUQ6
    8. NM_001430063.1NP_001416992.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P54311, Q6Q8B1, Q9QWG8
      UniProtKB/TrEMBL
      A6IUQ6
    9. NM_001430064.1NP_001416993.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P54311, Q6Q8B1, Q9QWG8
      UniProtKB/TrEMBL
      A6IUQ6
    10. NM_001430065.1NP_001416994.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P54311, Q6Q8B1, Q9QWG8
      UniProtKB/TrEMBL
      A6IUQ6
    11. NM_001430066.1NP_001416995.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P54311, Q6Q8B1, Q9QWG8
      UniProtKB/TrEMBL
      A6IUQ6
    12. NM_001430067.1NP_001416996.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P54311, Q6Q8B1, Q9QWG8
      UniProtKB/TrEMBL
      A6IUQ6
    13. NM_001430068.1NP_001416997.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P54311, Q6Q8B1, Q9QWG8
      UniProtKB/TrEMBL
      A6IUQ6
    14. NM_001430069.1NP_001416998.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P54311, Q6Q8B1, Q9QWG8
      UniProtKB/TrEMBL
      A6IUQ6
    15. NM_001430070.1NP_001416999.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P54311, Q6Q8B1, Q9QWG8
      UniProtKB/TrEMBL
      A6IUQ6
    16. NM_001430071.1NP_001417000.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P54311, Q6Q8B1, Q9QWG8
      UniProtKB/TrEMBL
      A6IUQ6
    17. NM_001430072.1NP_001417001.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P54311, Q6Q8B1, Q9QWG8
      UniProtKB/TrEMBL
      A6IUQ6
    18. NM_030987.3NP_112249.2  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      See identical proteins and their annotated locations for NP_112249.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P54311, Q6Q8B1, Q9QWG8
      UniProtKB/TrEMBL
      A6IUQ6
      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      171357778..171424489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287153.1XP_063143223.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    2. XM_008764335.4XP_008762557.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]
    3. XM_063287154.1XP_063143224.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    4. XM_063287155.1XP_063143225.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    5. XM_063287156.1XP_063143226.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    6. XM_039109260.2XP_038965188.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]
    7. XM_006239517.5XP_006239579.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      Related
      ENSRNOP00000044340.2, ENSRNOT00000041789.4
      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]
    8. XM_039109261.2XP_038965189.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]
    9. XM_039109262.2XP_038965190.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]
    10. XM_039109263.2XP_038965191.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]