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    Megf6 multiple EGF-like-domains 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65049, updated on 27-Nov-2024

    Summary

    Symbol
    Megf6provided by RGD
    Full Name
    multiple EGF-like-domains 6provided by RGD
    Primary source
    RGD:621188
    See related
    EnsemblRapid:ENSRNOG00000000156 AllianceGenome:RGD:621188
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Egfl3
    Summary
    Predicted to enable calcium ion binding activity and scavenger receptor activity. Predicted to be involved in vesicle-mediated transport. Predicted to be located in extracellular region. Orthologous to human MEGF6 (multiple EGF like domains 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 91.8), Thymus (RPKM 20.0) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Megf6 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (170020699..170121557)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (164738272..164839142)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (171588901..171620947)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene WD repeat containing, antisense to TP73 Neighboring gene tumor protein p63 regulated 1-like Neighboring gene Rho guanine nucleotide exchange factor 16 Neighboring gene PR/SET domain 16 Neighboring gene uncharacterized LOC102555433

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    multiple epidermal growth factor-like domains protein 6
    Names
    EGF-like domain-containing protein 3
    EGF-like-domain, multiple 3
    epidermal growth factor-like protein 3
    multiple EGF-like domain protein 3
    multiple EGF-like domains protein 6
    multiple epidermal growth factor-like domains 6
    multiple epidermal growth factor-like domains protein 6-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022955.1NP_075244.1  multiple epidermal growth factor-like domains protein 6 precursor

      See identical proteins and their annotated locations for NP_075244.1

      Status: PROVISIONAL

      Source sequence(s)
      AB011532
      UniProtKB/Swiss-Prot
      O88281
      Related
      ENSRNOP00000000169.7, ENSRNOT00000000169.8
      Conserved Domains (3) summary
      pfam07546
      Location:42112
      EMI; EMI domain
      pfam14670
      Location:338373
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:154202
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      170020699..170121557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110728.1XP_038966656.1  multiple epidermal growth factor-like domains protein 6 isoform X1

      Related
      ENSRNOP00000108057.1, ENSRNOT00000149353.1
      Conserved Domains (3) summary
      pfam07546
      Location:42112
      EMI; EMI domain
      pfam14670
      Location:127162
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:243284
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    2. XM_039110730.1XP_038966658.1  multiple epidermal growth factor-like domains protein 6 isoform X2

      UniProtKB/TrEMBL
      D4AA94
      Related
      ENSRNOP00000052252.5, ENSRNOT00000055386.6
      Conserved Domains (2) summary
      pfam14670
      Location:5994
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:175216
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...