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    Prkcz protein kinase C, zeta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25522, updated on 27-Nov-2024

    Summary

    Official Symbol
    Prkczprovided by RGD
    Official Full Name
    protein kinase C, zetaprovided by RGD
    Primary source
    RGD:3399
    See related
    EnsemblRapid:ENSRNOG00000015480 AllianceGenome:RGD:3399
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pkcz; r14-3-3; 14-3-3-zetaisoform
    Summary
    Enables several functions, including 14-3-3 protein binding activity; enzyme binding activity; and potassium channel regulator activity. Involved in several processes, including activation of phospholipase D activity; positive regulation of cell communication; and regulation of protein localization. Located in several cellular components, including cell leading edge; perinuclear region of cytoplasm; and stress fiber. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Used to study hyperglycemia. Biomarker of type 2 diabetes mellitus. Orthologous to human PRKCZ (protein kinase C zeta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 108.1), Kidney (RPKM 59.9) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Prkcz in Genome Data Viewer
    Location:
    5q36
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171101774..171212694, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (165817786..165930386, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (172658071..172769492, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692526 Neighboring gene FA core complex associated protein 20 Neighboring gene uncharacterized LOC134479059 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class P, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 14-3-3 protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium,diacylglycerol-dependent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables diacylglycerol-dependent serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables potassium channel regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in activation of phospholipase D activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in activation of protein kinase B activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to insulin stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to insulin stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in membrane depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in membrane hyperpolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron projection extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of T-helper 2 cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T-helper 2 cell cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of T-helper 2 cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T-helper 2 cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of excitatory postsynaptic potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-10 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-13 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-13 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-4 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-4 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-5 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-5 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle transport along microtubule IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in apical cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon hillock ISO
    Inferred from Sequence Orthology
    more info
     
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath abaxonal region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein kinase C zeta type
    Names
    nPKC-zeta
    NP_071952.1
    XP_006239598.1
    XP_038965237.1
    XP_038965239.1
    XP_038965240.1
    XP_063143261.1
    XP_063143263.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429418.1NP_001416347.1  protein kinase C zeta type isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
    2. NM_001429421.1NP_001416350.1  protein kinase C zeta type isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
    3. NM_001429422.1NP_001416351.1  protein kinase C zeta type isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
    4. NM_001429423.1NP_001416352.1  protein kinase C zeta type isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6IUP4
    5. NM_001429424.1NP_001416353.1  protein kinase C zeta type isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6IUP4
    6. NM_022507.2NP_071952.1  protein kinase C zeta type isoform 2

      See identical proteins and their annotated locations for NP_071952.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P09217
      UniProtKB/TrEMBL
      A6IUP2
      Related
      ENSRNOP00000021285.5, ENSRNOT00000021285.8
      Conserved Domains (4) summary
      cd06404
      Location:1698
      PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
      smart00220
      Location:252518
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam00130
      Location:131183
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl21453
      Location:236592
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      171101774..171212694 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109309.2XP_038965237.1  protein kinase C zeta type isoform X1

      Related
      ENSRNOP00000108141.1, ENSRNOT00000132708.1
      Conserved Domains (3) summary
      cd06404
      Location:1698
      PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
      cd05617
      Location:249605
      STKc_aPKC_zeta; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta
      cd21095
      Location:129183
      C1_aPKC_zeta; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) zeta type
    2. XM_006239536.5XP_006239598.1  protein kinase C zeta type isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:53409
      PKc_like; Protein Kinases, catalytic domain
    3. XM_039109312.2XP_038965240.1  protein kinase C zeta type isoform X5

      Conserved Domains (1) summary
      cl21453
      Location:66422
      PKc_like; Protein Kinases, catalytic domain
    4. XM_063287193.1XP_063143263.1  protein kinase C zeta type isoform X4

    5. XM_063287191.1XP_063143261.1  protein kinase C zeta type isoform X3

    6. XM_039109311.2XP_038965239.1  protein kinase C zeta type isoform X2

      Conserved Domains (2) summary
      cd05617
      Location:141497
      STKc_aPKC_zeta; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta
      cd21095
      Location:2175
      C1_aPKC_zeta; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) zeta type