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    Adam2 ADAM metallopeptidase domain 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 56806, updated on 27-Nov-2024

    Summary

    Official Symbol
    Adam2provided by RGD
    Official Full Name
    ADAM metallopeptidase domain 2provided by RGD
    Primary source
    RGD:69299
    See related
    EnsemblRapid:ENSRNOG00000017027 AllianceGenome:RGD:69299
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ftnb; PH-30
    Summary
    Predicted to enable metalloendopeptidase activity. Involved in male gonad development and spermatogenesis. Located in acrosomal vesicle. Orthologous to human ADAM2 (ADAM metallopeptidase domain 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 339.4) See more
    Orthologs
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    Genomic context

    See Adam2 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (44418191..44459570, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (40242651..40284025, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (42708536..42751281, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2 scaffold subunit A alpha, pseudogene 1 Neighboring gene clusterin Neighboring gene gulonolactone (L-) oxidase Neighboring gene uncharacterized LOC102555773 Neighboring gene epoxide hydrolase 2 Neighboring gene cholinergic receptor nicotinic alpha 2 subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in adult behavior IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within adult behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in male gonad development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in visual learning IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within visual learning ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 2
    Names
    A disintegrin and metalloprotease domain 2 (Fertilin beta)
    ADAM 2
    PH30
    PH30-beta
    a disintegrin and metallopeptidase domain 2
    a disintegrin and metalloprotease domain (ADAM) 2
    fertilin beta
    fertilin subunit beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020077.3NP_064462.2  disintegrin and metalloproteinase domain-containing protein 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6K6L5, F1M6W4
      Related
      ENSRNOP00000061122.4, ENSRNOT00000066478.5
      Conserved Domains (4) summary
      smart00050
      Location:398475
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:477613
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:184381
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:32147
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      44418191..44459570 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093614.2XP_038949542.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      F1M6W4
      Conserved Domains (4) summary
      smart00050
      Location:346423
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:425561
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:132329
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:32107
      Pep_M12B_propep; Reprolysin family propeptide
    2. XM_039093615.2XP_038949543.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X2

      Conserved Domains (3) summary
      smart00050
      Location:235312
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:314450
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:21218
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    3. XM_063274593.1XP_063130663.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X2

    4. XM_039093616.2XP_038949544.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X3

      Conserved Domains (3) summary
      smart00050
      Location:161238
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:240376
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:1144
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    5. XM_039093617.2XP_038949545.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X4

      Conserved Domains (3) summary
      smart00050
      Location:74151
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:153289
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:157
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease