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    Icmt isoprenylcysteine carboxyl methyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170818, updated on 9-Dec-2024

    Summary

    Official Symbol
    Icmtprovided by RGD
    Official Full Name
    isoprenylcysteine carboxyl methyltransferaseprovided by RGD
    Primary source
    RGD:621618
    See related
    EnsemblRapid:ENSRNOG00000010953 AllianceGenome:RGD:621618
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    fcmt
    Summary
    Enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity. Involved in C-terminal protein methylation; S-adenosylhomocysteine metabolic process; and S-adenosylmethioninamine metabolic process. Predicted to be located in cytoplasmic side of rough endoplasmic reticulum membrane. Predicted to be part of large ribosomal subunit. Predicted to be active in endoplasmic reticulum. Orthologous to human ICMT (isoprenylcysteine carboxyl methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 137.6), Kidney (RPKM 116.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Icmt in Genome Data Viewer
    Location:
    5q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (168084487..168097519)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (162804368..162811129)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (169475270..169482031)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 153 Neighboring gene hes family bHLH transcription factor 3 Neighboring gene ring finger protein 207 Neighboring gene ribosomal protein L22

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC95322

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in C-terminal protein methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within C-terminal protein methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in CAAX-box protein maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in S-adenosylhomocysteine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in S-adenosylmethioninamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within determination of adult lifespan ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within liver development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuromuscular process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein methylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasmic side of rough endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein-S-isoprenylcysteine O-methyltransferase
    Names
    PPMT
    farnesyl cysteine carboxyl methyltransferase
    pcCMT
    prenylated protein carboxyl methyltransferase
    prenylcysteine carboxyl methlytransferase
    prenylcysteine carboxyl methyltransferase
    NP_579844.2
    XP_063143178.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133310.2NP_579844.2  protein-S-isoprenylcysteine O-methyltransferase

      See identical proteins and their annotated locations for NP_579844.2

      Status: VALIDATED

      Source sequence(s)
      BC083923, CB616023
      UniProtKB/Swiss-Prot
      G3V7G5, Q9WVM4
      Conserved Domains (1) summary
      pfam04140
      Location:164257
      ICMT; Isoprenylcysteine carboxyl methyltransferase (ICMT) family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      168084487..168097519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287108.1XP_063143178.1  protein-S-isoprenylcysteine O-methyltransferase isoform X1

      Related
      ENSRNOP00000014625.4, ENSRNOT00000014625.7