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    Nadk NAD kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100125370, updated on 9-Dec-2024

    Summary

    Symbol
    Nadkprovided by RGD
    Full Name
    NAD kinaseprovided by RGD
    Primary source
    RGD:1642420
    See related
    EnsemblRapid:ENSRNOG00000016936 AllianceGenome:RGD:1642420
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable NAD+ kinase activity. Involved in NADP biosynthetic process and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Orthologous to human NADK (NAD kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 321.0), Adrenal (RPKM 304.3) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nadk in Genome Data Viewer
    Location:
    5q36
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171427973..171458586)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166145708..166176328)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (172984930..173015505)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 52 Neighboring gene G protein subunit beta 1 Neighboring gene uncharacterized LOC120103052 Neighboring gene ATP synthase peripheral stalk subunit d, pseudogene 1 Neighboring gene uncharacterized LOC134487048 Neighboring gene solute carrier family 35, member E2B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General protein information

    Preferred Names
    NAD kinase
    NP_001103148.1
    XP_006239575.1
    XP_006239576.1
    XP_038965017.1
    XP_038965018.1
    XP_038965019.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109678.1NP_001103148.1  NAD kinase

      See identical proteins and their annotated locations for NP_001103148.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473968
      UniProtKB/TrEMBL
      A0A8I5ZN26, A6IUQ7, F7EXV6
      Conserved Domains (1) summary
      cl01255
      Location:98429
      DAGK_cat; Diacylglycerol kinase catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      171427973..171458586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109091.2XP_038965019.1  NAD kinase isoform X5

      Conserved Domains (1) summary
      cl01255
      Location:130353
      DAGK_cat; Diacylglycerol kinase catalytic domain
    2. XM_039109089.2XP_038965017.1  NAD kinase isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZN26
      Conserved Domains (1) summary
      cl28462
      Location:128472
      pnk; bifunctional NADP phosphatase/NAD kinase
    3. XM_006239513.5XP_006239575.1  NAD kinase isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZN26, A0A8I6AFT7
      Related
      ENSRNOP00000093005.1, ENSRNOT00000094609.2
      Conserved Domains (1) summary
      cl01255
      Location:130461
      DAGK_cat; Diacylglycerol kinase catalytic domain
    4. XM_039109090.2XP_038965018.1  NAD kinase isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZN26, Q5FVF8
      Related
      ENSRNOP00000095842.2, ENSRNOT00000101792.2
      Conserved Domains (1) summary
      cl28462
      Location:96440
      pnk; bifunctional NADP phosphatase/NAD kinase
    5. XM_006239514.4XP_006239576.1  NAD kinase isoform X4

      See identical proteins and their annotated locations for XP_006239576.1

      UniProtKB/TrEMBL
      A0A8I5ZN26, A6IUQ7, F7EXV6
      Conserved Domains (1) summary
      cl01255
      Location:98429
      DAGK_cat; Diacylglycerol kinase catalytic domain