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    Ajap1 adherens junctions associated protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 687031, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ajap1provided by RGD
    Official Full Name
    adherens junctions associated protein 1provided by RGD
    Primary source
    RGD:1590138
    See related
    EnsemblRapid:ENSRNOG00000050137 AllianceGenome:RGD:1590138
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    neumo48
    Summary
    Predicted to enable beta-catenin binding activity and protein domain specific binding activity. Predicted to be involved in negative regulation of cell-matrix adhesion; negative regulation of wound healing; and regulation of polarized epithelial cell differentiation. Predicted to be located in basolateral plasma membrane and cell surface. Predicted to be active in adherens junction; cell-cell contact zone; and cytoplasmic side of plasma membrane. Orthologous to human AJAP1 (adherens junctions associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 65.6), Spleen (RPKM 4.3) and 1 other tissue See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ajap1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (169190477..169302938, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (163907846..164021004, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (170615885..170679315, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S15 like 1 Neighboring gene uncharacterized LOC102550429 Neighboring gene uncharacterized LOC134479054 Neighboring gene uncharacterized LOC120102801 Neighboring gene uncharacterized LOC120103047

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of polarized epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell-cell contact zone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell-cell contact zone ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    adherens junction-associated protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101014.2NP_001094484.1  adherens junction-associated protein 1 precursor

      See identical proteins and their annotated locations for NP_001094484.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q4W8E7
      UniProtKB/TrEMBL
      M0R546
      Related
      ENSRNOP00000093386.1, ENSRNOT00000100046.2
      Conserved Domains (1) summary
      pfam15298
      Location:180388
      AJAP1_PANP_C; AJAP1/PANP C-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      169190477..169302938 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110790.2XP_038966718.1  adherens junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q4W8E7
      UniProtKB/TrEMBL
      M0R546
      Conserved Domains (1) summary
      pfam15298
      Location:180388
      AJAP1_PANP_C; AJAP1/PANP C-terminus