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    RpLP0-like Ribosomal protein LP0-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36058, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RpLP0-likeprovided by FlyBase
    Official Full Name
    Ribosomal protein LP0-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033485
    Locus tag
    Dmel_CG1381
    See related
    AllianceGenome:FB:FBgn0033485
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1381; Dmel\CG1381; MRT4
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in nuclear-transcribed mRNA catabolic process; rRNA processing; and ribosomal large subunit biogenesis. Predicted to be part of cytosolic large ribosomal subunit and preribosome, large subunit precursor. Predicted to be active in nucleolus. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; larval muscle system; larval somatic muscle cell; and mesoderm. Orthologous to human MRTO4 (MRT4 homolog, ribosome maturation factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RpLP0-like in Genome Data Viewer
    Location:
    46E5-46E6; 2-62 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10098518..10099590, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5986023..5987095, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene snoRNA:Orphan C/D box 13 Neighboring gene eiger Neighboring gene uncharacterized protein Neighboring gene sugar transporter 4 Neighboring gene 14-3-3zeta Neighboring gene Jun-related antigen Neighboring gene Phosphofructokinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biosynthetic enzyme GMP synthetase cooperates with ubiquitin-specific protease 7 in transcriptional regulation of ecdysteroid target genes. van der Knaap JA, et al. Mol Cell Biol, 2010 Feb. PMID 19995917, Free PMC Article
    2. Upregulation of ribosome biogenesis via canonical E-boxes is required for Myc-driven proliferation. Zielke N, et al. Dev Cell, 2022 Apr 25. PMID 35472319
    3. Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila. Demontis F, et al. Development, 2009 Mar. PMID 19211682, Free PMC Article
    4. Temporal and sequential order of nonoverlapping gene networks unraveled in mated female Drosophila. Pasquier C, et al. Life Sci Alliance, 2022 Feb. PMID 34844981, Free PMC Article
    5. Ribosome heterogeneity in Drosophila melanogaster gonads through paralog-switching. Hopes T, et al. Nucleic Acids Res, 2022 Feb 28. PMID 34283226, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of ribosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    part_of cytosolic large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of cytosolic large ribosomal subunit TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein LP0-like
    Names
    CG1381-PA
    RpLP0-like-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10098518..10099590 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136710.4 → NP_610554.1  ribosomal protein LP0-like [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610554.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1Q7
      Related
      FBpp0087511
      Conserved Domains (1) summary
      cd05796
      Location:21 → 184
      Ribosomal_P0_like; Ribosomal protein L10 family, P0-like protein subfamily; composed of uncharacterized eukaryotic proteins with similarity to the 60S ribosomal protein P0, including the Saccharomyces cerevisiae protein called mRNA turnover protein 4 (MRT4). MRT4 may be ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K1Q7 Q7K1Q7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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