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    ast asteroid [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33282, updated on 9-Dec-2024

    Summary

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    Official Symbol
    astprovided by FlyBase
    Official Full Name
    asteroidprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015905
    Locus tag
    Dmel_CG4426
    See related
    AllianceGenome:FB:FBgn0015905
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Ast; CG4426; Dmel\CG4426; Star/asteroid; S[r]
    Summary
    Involved in compound eye photoreceptor fate commitment; imaginal disc-derived wing vein morphogenesis; and larval somatic muscle development. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; eye disc morphogenetic furrow; and posterior endoderm. Human ortholog(s) of this gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Orthologous to human ASTE1 (asteroid homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ast in Genome Data Viewer
    Location:
    21E4-21E4; 2-1.5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1077948..1080803)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1077948..1080803)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene IA-2 protein tyrosine phosphatase Neighboring gene germinal nascent polypeptide-associated complex alpha subunit Neighboring gene Star Neighboring gene Autophagy-related 4a Neighboring gene uncharacterized protein Neighboring gene RNA polymerase mitochondrial

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The molecular organization of the Star/asteroid region, a region necessary for proper eye development in Drosophila melanogaster. Higson TS, et al. Genome, 1993 Apr. PMID 8390385
    2. Edward Novitski: Drosophila virtuoso. Crow JF, et al. Genetics, 2006 Oct. PMID 17068121, Free PMC Article
    3. Pseudoallelism and gene evolution. LEWIS EB. Cold Spring Harb Symp Quant Biol, 1951. PMID 14942737
    4. The Drosophila gene asteroid encodes a novel protein and displays dosage-sensitive interactions with Star and Egfr. Kotarski MA, et al. Genome, 1998 Apr. PMID 9644838
    5. Characterization of Star and its interactions with sevenless and EGF receptor during photoreceptor cell development in Drosophila. Kolodkin AL, et al. Development, 1994 Jul. PMID 7924981

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye photoreceptor fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing vein morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    asteroid
    Names
    CG4426-PA
    Star-recessive
    ast-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1077948..1080803
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078727.3 → NP_523451.2  asteroid [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523451.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RJ71, O61517, Q960G8, Q9VPW1
      Related
      FBpp0077617
      Conserved Domains (1) summary
      pfam12813
      Location:115 → 354
      XPG_I_2; XPG domain containing
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPW1.1 Q9VPW1

    Gene LinkOut

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