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    Immp1l inner mitochondrial membrane peptidase subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691145, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Immp1lprovided by RGD
    Official Full Name
    inner mitochondrial membrane peptidase subunit 1provided by RGD
    Primary source
    RGD:1587441
    See related
    EnsemblRapid:ENSRNOG00000004829 AllianceGenome:RGD:1587441
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein processing involved in protein targeting to mitochondrion. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial inner membrane peptidase complex. Orthologous to human IMMP1L (inner mitochondrial membrane peptidase subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 220.8), Heart (RPKM 195.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Immp1l in Genome Data Viewer
    Location:
    3q33
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (112840015..112904297)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (92385329..92449559)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (95955126..96024316)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene paired box 6 Neighboring gene elongator acetyltransferase complex subunit 4 Neighboring gene ribosomal protein L35A like 6 Neighboring gene uncharacterized LOC120101618 Neighboring gene U2 spliceosomal RNA Neighboring gene DnaJ heat shock protein family (Hsp40) member C24 Neighboring gene doublecortin domain containing 1, pseudogene 1 Neighboring gene doublecortin domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Processing of mitochondrial presequences. Mossmann D, et al. Biochim Biophys Acta, 2012 Sep-Oct. PMID 22172993
    2. Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane. Burri L, et al. Mol Biol Cell, 2005 Jun. PMID 15814844, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein processing involved in protein targeting to mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial inner membrane peptidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial inner membrane protease subunit 1
    Names
    IMP1 inner mitochondrial membrane peptidase-like
    NP_001386571.1
    NP_001386572.1
    XP_006234731.1
    XP_063140663.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399642.1 → NP_001386571.1  mitochondrial inner membrane protease subunit 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HNX8, D3ZWF3
      Related
      ENSRNOP00000077722.2, ENSRNOT00000100315.2

    2. NM_001399643.1 → NP_001386572.1  mitochondrial inner membrane protease subunit 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HNX8, D3ZWF3
      Related
      ENSRNOP00000006406.5, ENSRNOT00000006406.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      112840015..112904297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234669.5 → XP_006234731.1  mitochondrial inner membrane protease subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZKD1
      Conserved Domains (2) summary
      cd06530
      Location:33 → 141
      S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...
      TIGR02227
      Location:29 → 144
      sigpep_I_bact; signal peptidase I, bacterial type

    2. XM_063284593.1 → XP_063140663.1  mitochondrial inner membrane protease subunit 1 isoform X1

      Related
      ENSRNOP00000101047.1, ENSRNOT00000125771.1
    Nucleotide Protein Strain
    Heading Accession and Version

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