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    Oseg1 Outer segment 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38957, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Oseg1provided by FlyBase
    Official Full Name
    Outer segment 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0265102
    Locus tag
    Dmel_CG7161
    See related
    AllianceGenome:FB:FBgn0265102
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7161; DAF-10; Dmel\CG7161; IFT122; mecC; OSEG; oseg1; OSEG1; OSM-4; Wdr10
    Summary
    Involved in intraciliary retrograde transport; non-motile cilium assembly; and positive regulation of canonical Wnt signaling pathway. Located in non-motile cilium. Is expressed in chordotonal neurons; chordotonal organ precursor cell; eo neurons; and larval antenno-maxillary sensory complex. Human ortholog(s) of this gene implicated in cranioectodermal dysplasia 1. Orthologous to human IFT122 (intraflagellar transport 122). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Oseg1 in Genome Data Viewer
    Location:
    66C11-66C11; 3-24 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8407268..8412825, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8400368..8405925, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Jonah 66Cii Neighboring gene uncharacterized protein Neighboring gene monkey king protein Neighboring gene tRNA 2'-phosphotransferase Neighboring gene uncharacterized protein Neighboring gene Exocyst 70 Neighboring gene matrimony Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel tools to unravel molecular mechanisms in cilia-related disorders. Fliegauf M, et al. Trends Genet, 2006 May. PMID 16564109
    2. dTULP, the Drosophila melanogaster homolog of tubby, regulates transient receptor potential channel localization in cilia. Park J, et al. PLoS Genet, 2013. PMID 24068974, Free PMC Article
    3. An IFT-A protein is required to delimit functionally distinct zones in mechanosensory cilia. Lee E, et al. Curr Biol, 2008 Dec 23. PMID 19097904, Free PMC Article
    4. Evolution of intraflagellar transport from coated vesicles and autogenous origin of the eukaryotic cilium. Jékely G, et al. Bioessays, 2006 Feb. PMID 16435301
    5. New Insights into the Genetic Basis of Monge's Disease and Adaptation to High-Altitude. Stobdan T, et al. Mol Biol Evol, 2017 Dec 1. PMID 29029226, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium assembly IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cilium assembly ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in intraciliary retrograde transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary retrograde transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in non-motile cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of intraciliary transport particle A IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intraciliary transport particle A ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in non-motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    outer segment 1
    Names
    CG7161-PA
    CG7161-PB
    Oseg1-PA
    Oseg1-PB
    mechanosensory C

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8407268..8412825 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300053.1 → NP_001286982.1  outer segment 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286982.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T9D3, Q9VSJ6
      Conserved Domains (4) summary
      COG2319
      Location:8 → 307
      WD40; WD40 repeat [General function prediction only]
      TIGR00540
      Location:598 → 789
      TPR_hemY_coli; heme biosynthesis-associated TPR protein
      sd00039
      Location:25 → 59
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:22 → 296
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_139964.3 → NP_648221.3  outer segment 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648221.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T9D3, Q9VSJ6
      Related
      FBpp0076386
      Conserved Domains (4) summary
      COG2319
      Location:8 → 307
      WD40; WD40 repeat [General function prediction only]
      TIGR00540
      Location:598 → 789
      TPR_hemY_coli; heme biosynthesis-associated TPR protein
      sd00039
      Location:25 → 59
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:22 → 296
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T9D3 Q8T9D3
    Q9VSJ6 Q9VSJ6

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