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    CG46491 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36929, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG46491provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0287631
    Locus tag
    Dmel_CG46491
    See related
    AllianceGenome:FB:FBgn0287631
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15612; CG15613; CG30456; Dmel\CG46491
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Involved in imaginal disc-derived leg morphogenesis. Is expressed in leg and spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG46491 in Genome Data Viewer
    Location:
    53F8-53F9; 2-81 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17100241..17107542)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12987746..12995047)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Glutathione S transferase S1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Amylase proximal

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Membrane phospholipid asymmetry counters the adverse effects of sterol overloading in the Golgi membrane of Drosophila. Ma Z, et al. Genetics, 2012 Apr. PMID 22234859, Free PMC Article
    2. Modulation of the activity of a polycomb-group response element in Drosophila by a mutation in the transcriptional activator woc. Noyes A, et al. G3 (Bethesda), 2011 Nov. PMID 22384357, Free PMC Article
    3. Systematic expression and loss-of-function analysis defines spatially restricted requirements for Drosophila RhoGEFs and RhoGAPs in leg morphogenesis. Greenberg L, et al. Mech Dev, 2011 Jan-Feb. PMID 20851182, Free PMC Article
    4. Genome-wide phenotypic RNAi screen in the Drosophila wing: global parameters. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599819, Free PMC Article
    5. Systematic analysis of RhoGEF/GAP localizations uncovers regulators of mechanosensing and junction formation during epithelial cell division. di Pietro F, et al. Curr Biol, 2023 Mar 13. PMID 36917931, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in imaginal disc-derived leg morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG46491-PB
    CG46491-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17100241..17107542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137344.4 → NP_611188.3  uncharacterized protein Dmel_CG46491, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611188.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAQ3, Q960B3
      Conserved Domains (1) summary
      pfam00621
      Location:326 → 470
      RhoGEF; RhoGEF domain

    2. NM_001274112.1 → NP_001261041.1  uncharacterized protein Dmel_CG46491, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261041.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEX9, Q960B3
      Conserved Domains (1) summary
      pfam00621
      Location:236 → 380
      RhoGEF; RhoGEF domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEX9 A0A0B4KEX9

    Gene LinkOut

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