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    bsf bicoid stability factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35100, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bsfprovided by FlyBase
    Official Full Name
    bicoid stability factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0284256
    Locus tag
    Dmel_CG10302
    See related
    AllianceGenome:FB:FBgn0284256
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Bsf; BSF; CG10302; Dmel\CG10302; dmlrpprc1; DmLrpprc1; DmLRPPRC1; l(2)SH1181; l(2)SH2 1181
    Summary
    Enables mRNA 3'-UTR binding activity. Involved in several processes, including RNA processing; positive regulation of oxidative phosphorylation; and regulation of mitochondrial gene expression. Located in H zone; Z disc; and mitochondrion. Is expressed in adult head; adult heart; organism; and primordial germ cell. Human ortholog(s) of this gene implicated in French Canadian Leigh disease and Leigh disease. Orthologous to human LRPPRC (leucine rich pentatricopeptide repeat containing). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See bsf in Genome Data Viewer
    Location:
    36F5-36F5; 2-53 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18449517..18454587, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18449517..18454587, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Ribosomal protein S26 Neighboring gene nucampholin Neighboring gene let-7 Complex Neighboring gene Nuclear transport factor-2-related Neighboring gene mir-100 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stable Isotope Labeling of Amino Acids in Flies (SILAF) Reveals Differential Phosphorylation of Mitochondrial Proteins Upon Loss of OXPHOS Subunits. Rosenberger FA, et al. Mol Cell Proteomics, 2021. PMID 33640490, Free PMC Article
    2. BSF binds specifically to the bicoid mRNA 3' untranslated region and contributes to stabilization of bicoid mRNA. Mancebo R, et al. Mol Cell Biol, 2001 May. PMID 11313472, Free PMC Article
    3. CGG repeat expansion in NOTCH2NLC causes mitochondrial dysfunction and progressive neurodegeneration in Drosophila model. Yu J, et al. Proc Natl Acad Sci U S A, 2022 Oct 11. PMID 36191230, Free PMC Article
    4. Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA in vivo. Pajak A, et al. PLoS Genet, 2019 Jul. PMID 31365523, Free PMC Article
    5. The PPR domain of mitochondrial RNA polymerase is an exoribonuclease required for mtDNA replication in Drosophila melanogaster. Liu Y, et al. Nat Cell Biol, 2022 May. PMID 35449456

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Although the C region of the osk 3' UTR is required for the noncoding function, BSF binding does not appear to be essential for that function.
      Title: RNA sequences required for the noncoding function of oskar RNA also mediate regulation of Oskar protein expression by Bicoid Stability Factor.
    2. Epistasis studies showed that Mbl silencing was sufficient to induce a subcellular redistribution of TBPH and BSF proteins in the muscle, which mimicked the effect of i(CTG)480 expression.
      Title: Muscleblind, BSF and TBPH are mislocalized in the muscle sarcomere of a Drosophila myotonic dystrophy model.
    3. it reports of a novel function of BSF in flies and demonstrates that it has an important intra-mitochondrial role, which is essential for maintaining mtDNA gene expression and oxidative phosphorylation.
      Title: The bicoid stability factor controls polyadenylation and expression of specific mitochondrial mRNAs in Drosophila melanogaster.
    4. activation of the zygotic genome starts from intronless genes sharing a common cis-element. This cis-element interacts with a single protein, Bicoid stability factor, & acts as potent enhancer capable of timing activity of an exogenous transactivator.
      Title: Unmasking activation of the zygotic genome using chromosomal deletions in the Drosophila embryo.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial mRNA polyadenylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polycistronic mRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of oxidative phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitochondrial gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitochondrial mRNA stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitochondrial transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in H zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial matrix IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bicoid stability factor
    Names
    CG10302-PA
    bicoid stabilization factor
    bsf-PA
    lethal (2) SH1181

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18449517..18454587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078872.5 → NP_523596.2  bicoid stability factor [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523596.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95NR4, Q9VJ86
      Related
      FBpp0080637
      Conserved Domains (4) summary
      sd00004
      Location:177 → 204
      PPR; PPR repeat [structural motif]
      pfam12854
      Location:169 → 202
      PPR_1; PPR repeat
      pfam13041
      Location:173 → 222
      PPR_2; PPR repeat family
      cl00219
      Location:456 → 543
      Pterin_binding; Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95NR4 Q95NR4
    Q9VJ86 Q9VJ86

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