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    Yod1 Yod1 deubiquitinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38603, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Yod1provided by FlyBase
    Official Full Name
    Yod1 deubiquitinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035593
    Locus tag
    Dmel_CG4603
    See related
    AllianceGenome:FB:FBgn0035593
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4603; Dmel\CG4603; dYOD1; Otu1; Q9VRJ9
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Involved in positive regulation of double-strand break repair. Orthologous to human YOD1 (YOD1 deubiquitinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Yod1 in Genome Data Viewer
    Location:
    64C7-64C7; 3-13 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5133871..5135670)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5126971..5128770)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45160 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Threonyl-carbamoyl synthesis 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ubiquitin thioesterase YOD1 ameliorates mutant Huntingtin induced pathology in Drosophila. Farkas A, et al. Sci Rep, 2023 Dec 11. PMID 38081944, Free PMC Article
    2. The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. Bingol B, et al. Nature, 2014 Jun 19. PMID 24896179
    3. Deubiquitylases from genes to organism. Clague MJ, et al. Physiol Rev, 2013 Jul. PMID 23899565
    4. Systematic analysis of the physiological importance of deubiquitinating enzymes. Tsou WL, et al. PLoS One, 2012. PMID 22937016, Free PMC Article
    5. Usp5, Usp34, and Otu1 deubiquitylases mediate DNA repair in Drosophila melanogaster. Páhi ZG, et al. Sci Rep, 2022 Apr 7. PMID 35393473, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The ubiquitin thioesterase YOD1 ameliorates mutant Huntingtin induced pathology in Drosophila.
      Title: The ubiquitin thioesterase YOD1 ameliorates mutant Huntingtin induced pathology in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Yod1 deubiquitinase
    Names
    CG4603-PA
    CG4603-PB
    CG4603-PC
    Yod1-PA
    Yod1-PB
    Yod1-PC
    NP_001261435.1
    NP_001261436.1
    NP_647951.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5133871..5135670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274507.1 → NP_001261436.1  Yod1 deubiquitinase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261436.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T9H3, Q9VRJ9
      UniProtKB/TrEMBL
      B6IDQ5
      Conserved Domains (3) summary
      smart00213
      Location:5 → 80
      UBQ; Ubiquitin homologues
      COG5539
      Location:158 → 346
      COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]
      cl00155
      Location:10 → 80
      UBQ; Ubiquitin-like proteins

    2. NM_139694.4 → NP_647951.2  Yod1 deubiquitinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647951.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T9H3, Q9VRJ9
      UniProtKB/TrEMBL
      B6IDQ5
      Related
      FBpp0076867
      Conserved Domains (3) summary
      smart00213
      Location:5 → 80
      UBQ; Ubiquitin homologues
      COG5539
      Location:158 → 346
      COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]
      cl00155
      Location:10 → 80
      UBQ; Ubiquitin-like proteins

    3. NM_001274506.1 → NP_001261435.1  Yod1 deubiquitinase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261435.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PED6
      Conserved Domains (3) summary
      smart00213
      Location:5 → 80
      UBQ; Ubiquitin homologues
      COG5539
      Location:158 → 346
      COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]
      cl00155
      Location:10 → 80
      UBQ; Ubiquitin-like proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B6IDQ5 B6IDQ5
    M9PED6 M9PED6
    Q9VRJ9.1 Q9VRJ9

    Gene LinkOut

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