Pex12 Peroxin 12 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pex12provided by FlyBase
Official Full Name: Peroxin 12provided by FlyBase
Primary source: FLYBASE:FBgn0031282
Locus tag: Dmel_CG3639
See related: AllianceGenome:FB:FBgn0031282
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3639; DmelPex12; Dmel\CG3639; pex12; PEX12
Summary: Predicted to enable protein transmembrane transporter activity and ubiquitin protein ligase activity. Involved in peroxisome organization. Located in peroxisome. Is expressed in adult head. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 3A and peroxisome biogenesis disorder 3B. Orthologous to human PEX12 (peroxisomal biogenesis factor 12). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (815993..818096)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (815993..818096)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables protein transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in peroxisome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome organization	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein import into peroxisome matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into peroxisome matrix	IEA Inferred from Electronic Annotation more info
involved_in protein import into peroxisome matrix, receptor recycling	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein monoubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of peroxisomal importomer complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
is_active_in peroxisomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain