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    EMC4 ER membrane protein complex subunit 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40505, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EMC4provided by FlyBase
    Official Full Name
    ER membrane protein complex subunit 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0037199
    Locus tag
    Dmel_CG11137
    See related
    AllianceGenome:FB:FBgn0037199
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD31024; CG11137; CT31141; Dmel\CG11137; emc4
    Summary
    Contributes to membrane insertase activity. Involved in tail-anchored membrane protein insertion into ER membrane. Located in endomembrane system. Part of EMC complex. Is expressed in adult head; adult heart; and organism. Orthologous to human EMC4 (ER membrane protein complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See EMC4 in Genome Data Viewer
    Location:
    80B1-80B1; 3-47 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22867175..22868243, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22860588..22861343, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ADP ribosylation factor 1 Neighboring gene antisense RNA:CR45969

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ER complex proteins are required for rhodopsin biosynthesis and photoreceptor survival in Drosophila and mice. Xiong L, et al. Cell Death Differ, 2020 Feb. PMID 31263175, Free PMC Article
    2. EMC is required for biogenesis of Xport-A, an essential chaperone of Rhodopsin-1 and the TRP channel. Gaspar CJ, et al. EMBO Rep, 2022 Jan 5. PMID 34918864, Free PMC Article
    3. Microarray analysis of juvenile hormone response in Drosophila melanogaster S2 cells. Willis DK, et al. J Insect Sci, 2010. PMID 20672983, Free PMC Article
    4. Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability. Dutta D, et al. Proc Natl Acad Sci U S A, 2024 Feb 27. PMID 38381787, Free PMC Article
    5. FISH analysis of Drosophila melanogaster heterochromatin using BACs and P elements. Corradini N, et al. Chromosoma, 2003 Jul. PMID 12827380

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to membrane insertase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tail-anchored membrane protein insertion into ER membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of EMC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of EMC complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in endomembrane system HDA PubMed 

    General protein information

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    Preferred Names
    ER membrane protein complex subunit 4
    Names
    CG11137-PA
    CG11137-PB
    EMC4-PA
    EMC4-PB
    endoplasmic reticulum membrane protein complex 4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      22867175..22868243 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316459.1 → NP_001303388.1  ER membrane protein complex subunit 4, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNQ3
      Conserved Domains (1) summary
      pfam06417
      Location:43 → 152
      DUF1077; Protein of unknown function (DUF1077)

    2. NM_141167.3 → NP_649424.1  ER membrane protein complex subunit 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649424.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNQ3
      Related
      FBpp0078227
      Conserved Domains (1) summary
      pfam06417
      Location:43 → 152
      DUF1077; Protein of unknown function (DUF1077)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VNQ3 Q9VNQ3

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