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    spt4 spt4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36387, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spt4provided by FlyBase
    Official Full Name
    spt4provided by FlyBase
    Primary source
    FLYBASE:FBgn0028683
    Locus tag
    Dmel_CG12372
    See related
    AllianceGenome:FB:FBgn0028683
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    142904_at; CG12372; dDSIF; Dmel\CG12372; DSIF; dspt4; dSpt4; Dspt4; l(2)k05316; Spt4; SPT4
    Summary
    Contributes to RNA polymerase II complex binding activity. Involved in negative regulation of DNA-templated transcription, elongation; negative regulation of transcription by RNA polymerase II; and transcription elongation by RNA polymerase II. Located in nucleus; polytene chromosome interband; and polytene chromosome puff. Part of DSIF complex. Orthologous to human SUPT4H1 (SPT4 homolog, DSIF elongation factor subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See spt4 in Genome Data Viewer
    Location:
    49B10-49B10; 2-67 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12633589..12634172)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8521094..8521677)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene muskelin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mevalonate kinase Neighboring gene Imitation SWI Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNA polymerase II pausing and transcriptional regulation of the HSP70 expression. Bunch H. Eur J Cell Biol, 2017 Dec. PMID 29017815
    2. New Roles for Canonical Transcription Factors in Repeat Expansion Diseases. Goodman LD, et al. Trends Genet, 2020 Feb. PMID 31837826, Free PMC Article
    3. Identification of Regions in the Spt5 Subunit of DRB Sensitivity-inducing Factor (DSIF) That Are Involved in Promoter-proximal Pausing. Qiu Y, et al. J Biol Chem, 2017 Mar 31. PMID 28213523, Free PMC Article
    4. A fluorescent quantitative PCR approach to map gene deletions in the Drosophila genome. Chiang PW, et al. Genetics, 1999 Nov. PMID 10545461, Free PMC Article
    5. Facts about FACT and transcript elongation through chromatin. Belotserkovskaya R, et al. Curr Opin Genet Dev, 2004 Apr. PMID 15196460

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of the interactions between DSIF (DRB sensitivity inducing factor), NELF (negative elongation factor), and the Drosophila RNA polymerase II transcription elongation complex
      Title: Interactions between DSIF (DRB sensitivity inducing factor), NELF (negative elongation factor), and the Drosophila RNA polymerase II transcription elongation complex.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to RNA polymerase II complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription, elongation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription, elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA-templated transcription, elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription elongation-coupled chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of DSIF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DSIF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in polytene chromosome interband IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome puff IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription elongation factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    spt4
    Names
    CG12372-PA
    DSIF
    spt4-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12633589..12634172
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136958.5 → NP_610802.1  spt4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610802.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9TVQ5, Q9V6E5
      UniProtKB/TrEMBL
      A0A1B2AL22
      Related
      FBpp0086953
      Conserved Domains (1) summary
      cd07973
      Location:11 → 108
      Spt4; Transcription elongation factor Spt4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TVQ5.1 Q9TVQ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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    Molecular Biology Databases
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