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    Fancm Fanconi anemia group M helicase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42543, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fancmprovided by FlyBase
    Official Full Name
    Fanconi anemia group M helicaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038889
    Locus tag
    Dmel_CG7922
    See related
    AllianceGenome:FB:FBgn0038889
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg7922; CG7922; Dmel\CG7922; fancm
    Summary
    Enables 3'-5' DNA helicase activity. Involved in DNA duplex unwinding; DNA recombination; and negative regulation of mitotic recombination. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 15 and spermatogenic failure 28. Orthologous to human FANCM (FA complementation group M). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Fancm in Genome Data Viewer
    Location:
    93E2-93E2; 3-72 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21482325..21487444)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17308047..17313166)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ladybird early Neighboring gene long non-coding RNA:CR43453 Neighboring gene long non-coding RNA:CR44032 Neighboring gene C15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical Activities and Genetic Functions of the Drosophila melanogaster Fancm Helicase in DNA Repair. Romero NE, et al. Genetics, 2016 Oct. PMID 27466228, Free PMC Article
    2. Division of Labor by the HELQ, BLM, and FANCM Helicases during Homologous Recombination Repair in Drosophila melanogaster. Thomas A, et al. Genes (Basel), 2022 Mar 8. PMID 35328029, Free PMC Article
    3. A high-resolution whole-genome map of key chromatin modifications in the adult Drosophila melanogaster. Yin H, et al. PLoS Genet, 2011 Dec. PMID 22194694, Free PMC Article
    4. A concerted action of a paired-type homeobox gene, aristaless, and a homolog of Hox11/tlx homeobox gene, clawless, is essential for the distal tip development of the Drosophila leg. Kojima T, et al. Dev Biol, 2005 Mar 15. PMID 15733670
    5. Drosophila FANCM helicase prevents spontaneous mitotic crossovers generated by the MUS81 and SLX1 nucleases. Kuo HK, et al. Genetics, 2014 Nov. PMID 25205745, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3'-5' DNA helicase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables 3'-5' DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables four-way junction DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables four-way junction helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via synthesis-dependent strand annealing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via synthesis-dependent strand annealing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in interstrand cross-link repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of mitotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in recombinational repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    fanconi anemia group M helicase
    Names
    CG7922-PA
    CG7922-PB
    Fancm-PA
    Fancm-PB
    fanconi anemia group M (FANCM) helicase
    NP_001262806.1
    NP_650971.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21482325..21487444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275877.1 → NP_001262806.1  fanconi anemia group M helicase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262806.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VDA0, R4SCI1
      Conserved Domains (4) summary
      COG1111
      Location:43 → 608
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd12091
      Location:269 → 378
      FANCM_ID; Insert domain of FANCM and related proteins
      pfam00271
      Location:417 → 539
      Helicase_C; Helicase conserved C-terminal domain
      pfam04851
      Location:55 → 221
      ResIII; Type III restriction enzyme, res subunit

    2. NM_142714.3 → NP_650971.2  fanconi anemia group M helicase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650971.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VDA0, R4SCI1
      Conserved Domains (4) summary
      COG1111
      Location:43 → 608
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd12091
      Location:269 → 378
      FANCM_ID; Insert domain of FANCM and related proteins
      pfam00271
      Location:417 → 539
      Helicase_C; Helicase conserved C-terminal domain
      pfam04851
      Location:55 → 221
      ResIII; Type III restriction enzyme, res subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VDA0 Q9VDA0
    Q9VDA0.2

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