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    APC4 Anaphase Promoting Complex subunit 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31835, updated on 9-Dec-2024

    Summary

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    Official Symbol
    APC4provided by FlyBase
    Official Full Name
    Anaphase Promoting Complex subunit 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0052707
    Locus tag
    Dmel_CG32707
    See related
    AllianceGenome:FB:FBgn0052707
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32707; CG4350; Dmel\CG32707
    Summary
    Involved in protein catabolic process. Predicted to be part of anaphase-promoting complex. Predicted to be active in nuclear periphery. Is expressed in organism. Orthologous to human ANAPC4 (anaphase promoting complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See APC4 in Genome Data Viewer
    Location:
    8C4-8C7; 1-26 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9082931..9085867)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8976964..8979900)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Heterochromatin Protein 1b Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HP1B is a euchromatic Drosophila HP1 homolog with links to metabolism. Mills BB, et al. PLoS One, 2018. PMID 30346969, Free PMC Article
    2. PP1-mediated moesin dephosphorylation couples polar relaxation to mitotic exit. Kunda P, et al. Curr Biol, 2012 Feb 7. PMID 22209527
    3. The conserved discs-large binding partner Banderuola regulates asymmetric cell division in Drosophila. Mauri F, et al. Curr Biol, 2014 Aug 18. PMID 25088559
    4. Transcription-independent function of Polycomb group protein PSC in cell cycle control. Mohd-Sarip A, et al. Science, 2012 May 11. PMID 22491092
    5. The anaphase-promoting complex: it's not just for mitosis any more. Harper JW, et al. Genes Dev, 2002 Sep 1. PMID 12208841

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mitotic metaphase/anaphase transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of anaphase-promoting complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    anaphase promoting complex subunit 4
    Names
    APC4-PA
    APC4-PC
    CG32707-PA
    CG32707-PC
    anaphase promoting complex 4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9082931..9085867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132294.3 → NP_572522.2  anaphase promoting complex subunit 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572522.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95R47, Q9W395
      Related
      FBpp0071222
      Conserved Domains (3) summary
      pfam12894
      Location:6 → 52
      ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain
      pfam12896
      Location:222 → 418
      ANAPC4; Anaphase-promoting complex, cyclosome, subunit 4
      sd00039
      Location:20 → 54
      7WD40; WD40 repeat [structural motif]

    2. NM_001169243.3 → NP_001162714.2  anaphase promoting complex subunit 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162714.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJG4, Q95R47
      Conserved Domains (3) summary
      pfam12894
      Location:6 → 52
      ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain
      pfam12896
      Location:222 → 416
      ANAPC4; Anaphase-promoting complex, cyclosome, subunit 4
      sd00039
      Location:20 → 54
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JJG4 E1JJG4
    Q95R47 Q95R47
    Q9W395 Q9W395

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