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    Dab Disabled [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39866, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Dabprovided by FlyBase
    Official Full Name
    Disabledprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000414
    Locus tag
    Dmel_CG9695
    See related
    AllianceGenome:FB:FBgn0000414
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cDNA C; CG9695; dab; Dmel\CG9695
    Summary
    Enables sevenless binding activity. Involved in several processes, including endocytosis; nervous system development; and positive regulation of sevenless signaling pathway. Located in axon and cytosol. Is expressed in several structures, including adult head; mesoderm; peripheral nervous system; presumptive embryonic/larval central nervous system; and somatic muscle cell. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 37. Orthologous to several human genes including DAB1 (DAB adaptor protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dab in Genome Data Viewer
    Location:
    73C1-73C1; 3-44 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16712126..16724575)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16705226..16717675)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene lasp Neighboring gene long non-coding RNA:CR45897 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Peptidoglycan recognition protein SB2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A phosphotyrosine interaction domain. Bork P, et al. Cell, 1995 Mar 10. PMID 7534213
    2. Lipophorin receptors regulate mushroom body development and complex behaviors in Drosophila. Rojo-Cortés F, et al. BMC Biol, 2022 Sep 7. PMID 36071487, Free PMC Article
    3. Getting a Notch closer to renal dysfunction: activated Notch suppresses expression of the adaptor protein Disabled-2 in tubular epithelial cells. Schütte-Nütgen K, et al. FASEB J, 2019 Jan. PMID 30052485
    4. Functions of WW domains in the nucleus. Sudol M, et al. FEBS Lett, 2001 Feb 16. PMID 11223034
    5. The Drosophila Abelson proto-oncogene homolog: identification of mutant alleles that have pleiotropic effects late in development. Henkemeyer MJ, et al. Cell, 1987 Dec 4. PMID 3119227

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results report a Drosophila disabled (DAB)mutant revealing a novel role for DAB proteins in chemical synaptic transmission, and support a role for clathrin-mediated endocytosis in rapid clearance of neurotransmitter release sites.
      Title: The DISABLED protein functions in CLATHRIN-mediated synaptic vesicle endocytosis and exoendocytic coupling at the active zone.
    2. Dab is a bona fide component of the core Abl signaling pathway in Drosophila.
      Title: Disabled is a bona fide component of the Abl signaling network.
    3. Signalling from the pTyr (YB) Neu (ErbB-2) autophosphorylation site was affected by a haplosufficiency in drk (Grb-2), and in genes thought to function downstream of Grb-2: dab, sos, csw (Shp-2), and dos (Gab-1).
      Title: Genetic identification of effectors downstream of Neu (ErbB-2) autophosphorylation sites in a Drosophila model.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sevenless binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling adaptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellularization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in clathrin-dependent endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in compound eye photoreceptor development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mushroom body development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of sevenless signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    disabled
    Names
    CG9695-PA
    CG9695-PC
    CG9695-PD
    CG9695-PE
    CG9695-PF
    CG9695-PG
    CG9695-PH
    CG9695-PI
    Dab-PA
    Dab-PC
    Dab-PD
    Dab-PE
    Dab-PF
    Dab-PG
    Dab-PH
    Dab-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16712126..16724575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259872.1 → NP_001246801.1  disabled, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246801.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NEC1
      Conserved Domains (1) summary
      cd01215
      Location:10 → 157
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

    2. NM_001275038.1 → NP_001261967.1  disabled, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261967.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFS5
      Conserved Domains (1) summary
      cd01215
      Location:10 → 157
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

    3. NM_001259871.1 → NP_001246800.1  disabled, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246800.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDT7
      Conserved Domains (1) summary
      cd01215
      Location:10 → 157
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

    4. NM_079395.4 → NP_524119.2  disabled, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524119.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P98081, Q9VV93
      Related
      FBpp0075077
      Conserved Domains (1) summary
      cd01215
      Location:35 → 181
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

    5. NM_001169984.3 → NP_001163455.2  disabled, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163455.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JI13
      Conserved Domains (1) summary
      cd01215
      Location:35 → 181
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

    6. NM_001275040.1 → NP_001261969.1  disabled, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261969.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCU3
      Conserved Domains (1) summary
      cd01215
      Location:35 → 181
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

    7. NM_001275039.1 → NP_001261968.1  disabled, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261968.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PI84
      Conserved Domains (1) summary
      cd01215
      Location:35 → 181
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

    8. NM_001259873.1 → NP_001246802.1  disabled, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246802.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NG14
      Conserved Domains (1) summary
      cd01215
      Location:35 → 181
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JI13 E1JI13
    M9NDT7 M9NDT7
    M9NEC1 M9NEC1
    M9NG14 M9NG14
    M9PCU3 M9PCU3
    M9PFS5 M9PFS5
    M9PI84 M9PI84
    P98081.2 P98081

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