spn-B spindle B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: spn-Bprovided by FlyBase
Official Full Name: spindle Bprovided by FlyBase
Primary source: FLYBASE:FBgn0003480
Locus tag: Dmel_CG3325
See related: AllianceGenome:FB:FBgn0003480
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3325; Dmel\CG3325; Rad51; rad51-like; Rad51-like; Spn-B; SPN-B; spnB; SpnB; XRCC3
Summary: Predicted to enable ATP binding activity; ATP-dependent DNA damage sensor activity; and DNA binding activity. Predicted to contribute to four-way junction DNA binding activity. Involved in intracellular mRNA localization; oogenesis; and specification of axis polarity. Predicted to be part of Rad51C-XRCC3 complex. Predicted to be active in replication fork. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); central nervous system cancer (multiple); familial melanoma; multiple myeloma; and pancreatic cancer. Orthologous to human XRCC3 (X-ray repair cross complementing 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 88B4-88B4; 3-55 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (14328051..14329608)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (10153773..10155330)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we show that fork progression is enhanced in the absence of both Drosophila Rad51 homologs, spindle-A and spindle-B, revealing homologous recombination is active and actually impairs fork movement during follicle cell rereplication
Title: Multiple mechanisms contribute to double-strand break repair at rereplication forks in Drosophila follicle cells.
reducing the function of eIF1A in spnB ovaries suppresses the ventralized eggshell phenotype by restoring Grk expression
Title: Repression of Gurken translation by a meiotic checkpoint in Drosophila oogenesis is suppressed by a reduction in the dose of eIF1A.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent DNA damage sensor activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to four-way junction DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA recombination	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in DNA repair	NAS Non-traceable Author Statement more info	PubMed
involved_in chromosome condensation	TAS Traceable Author Statement more info	PubMed
involved_in double-strand break repair	TAS Traceable Author Statement more info	PubMed
involved_in double-strand break repair via synthesis-dependent strand annealing	IBA Inferred from Biological aspect of Ancestor more info
involved_in germarium-derived oocyte fate determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular mRNA localization	TAS Traceable Author Statement more info	PubMed
involved_in oocyte fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte karyosome formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oogenesis	TAS Traceable Author Statement more info	PubMed
involved_in polarity specification of anterior/posterior axis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polarity specification of dorsal/ventral axis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reciprocal meiotic recombination	TAS Traceable Author Statement more info	PubMed
involved_in regulation of translation	TAS Traceable Author Statement more info	PubMed
involved_in resolution of mitotic recombination intermediates	IBA Inferred from Biological aspect of Ancestor more info
involved_in t-circle formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance via recombination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Rad51C-XRCC3 complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in replication fork	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: spindle B

Names: CG3325-PA; Spindle-B; SpindleB; spn-B-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

14328051..14329608

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057392.5 → NP_476740.1 spindle B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476740.1

Status: REVIEWED

UniProtKB/TrEMBL

B6UY20, O77135, Q8SZF1

Related

FBpp0082392

Conserved Domains (2) summary

cd01123
Location:88 → 324

Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...

pfam08423
Location:87 → 323

Rad51; Rad51