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    Gem3 Gemin 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39195, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gem3provided by FlyBase
    Official Full Name
    Gemin 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0011802
    Locus tag
    Dmel_CG6539
    See related
    AllianceGenome:FB:FBgn0011802
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA.LD05563; BcDNA:LD05563; CG6539; dGem3; Dhh1; DHH1; Dmel\CG6539; DmRH22; gemin3; GEMIN3; l(3)rL562
    Summary
    Predicted to enable RNA helicase activity and mRNA binding activity. Involved in flight behavior; neuromuscular junction development; and protein-RNA complex assembly. Located in Cajal body; Gemini of coiled bodies; and cytoplasm. Part of SMN complex and cytoplasmic U snRNP body. Is expressed in eye disc; nurse cell; and oocyte. Orthologous to human DDX20 (DEAD-box helicase 20). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gem3 in Genome Data Viewer
    Location:
    67E3-67E3; 3-33 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (10459081..10463101, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (10452181..10456201, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 67b Neighboring gene Ionotropic receptor 67c Neighboring gene uncharacterized protein Neighboring gene Sperm-Leucylaminopeptidase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conserved requirement for DEAD-box RNA helicase Gemin3 in Drosophila oogenesis. Cauchi RJ. BMC Res Notes, 2012 Feb 23. PMID 22361416, Free PMC Article
    2. When one plus one equals three: biochemistry and bioinformatics combine to answer complex questions. Kroiss M, et al. Fly (Austin), 2009 Jul-Sep. PMID 19625772
    3. Gem formation upon constitutive Gemin3 overexpression in Drosophila. Cauchi RJ. Cell Biol Int, 2011 Dec. PMID 21627586
    4. SMA-causing missense mutations in survival motor neuron (Smn) display a wide range of phenotypes when modeled in Drosophila. Praveen K, et al. PLoS Genet, 2014 Aug. PMID 25144193, Free PMC Article
    5. Genetic Interactions between the Members of the SMN-Gemins Complex in Drosophila. Borg RM, et al. PLoS One, 2015. PMID 26098872, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SMN complex member Gemin3 self-interacts and has a functional relationship with ALS-linked proteins TDP-43, FUS and Sod1.
      Title: SMN complex member Gemin3 self-interacts and has a functional relationship with ALS-linked proteins TDP-43, FUS and Sod1.
    2. Data show that Gemin3 was required for the completion of oogenesis and its loss led to egg polarity defects, oocyte mislocalisation, and abnormal chromosome morphology.
      Title: Conserved requirement for DEAD-box RNA helicase Gemin3 in Drosophila oogenesis.
    3. Gemin3 overexpression in Drosophila
      Title: Gem formation upon constitutive Gemin3 overexpression in Drosophila.
    4. Gemin2, Gemin3 and Gemin5 colocalise with SMN in U bodies
      Title: Drosophila SMN complex proteins Gemin2, Gemin3, and Gemin5 are components of U bodies.
    5. Results demonstrate the conservation of Gemin3 (Gem3) protein function in metazoan snRNP assembly and reveal that loss of either survival motor neuron (Smn) or Gemin3 can contribute to neuromuscular dysfunction.
      Title: Gemin3 is an essential gene required for larval motor function and pupation in Drosophila.
    6. Drosophila Gemin3 is required for larval development and motor function.
      Title: A motor function for the DEAD-box RNA helicase, Gemin3, in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in flight behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein-RNA complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spliceosomal snRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal snRNP assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Gemini of coiled bodies IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SMN complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SMN complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SMN complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytoplasmic U snRNP body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gemin 3
    Names
    CG6539-PA
    CG6539-PB
    DEAD/DEAH RNA helicase 1
    Gem3-PA
    Gem3-PB
    dGemin3
    gemin3
    NP_001261678.1
    NP_524019.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      10459081..10463101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274749.1 → NP_001261678.1  gemin 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261678.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3C4
      Conserved Domains (3) summary
      COG0513
      Location:24 → 541
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      pfam00271
      Location:259 → 367
      Helicase_C; Helicase conserved C-terminal domain
      cl21455
      Location:27 → 228
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_079295.4 → NP_524019.1  gemin 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524019.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3C4
      Related
      FBpp0076021
      Conserved Domains (3) summary
      COG0513
      Location:24 → 541
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      pfam00271
      Location:259 → 367
      Helicase_C; Helicase conserved C-terminal domain
      cl21455
      Location:27 → 228
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3C4 Q9V3C4

    Gene LinkOut

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