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    phr6-4 (6-4)-photolyase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35322, updated on 9-Dec-2024

    Summary

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    Official Symbol
    phr6-4provided by FlyBase
    Official Full Name
    (6-4)-photolyaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0016054
    Locus tag
    Dmel_CG2488
    See related
    AllianceGenome:FB:FBgn0016054
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    38D.25; 6-4 PHR; 64-PL; 64PHR; CG2488; D6-4; Dm 64; Dmel\CG2488; phr(6-4)
    Summary
    Predicted to enable DNA binding activity; FAD binding activity; and deoxyribodipyrimidine photo-lyase activity. Predicted to be involved in circadian regulation of gene expression and entrainment of circadian clock by photoperiod. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; embryonic/larval midgut primordium; and gonad. Human ortholog(s) of this gene implicated in delayed sleep phase syndrome. Orthologous to human CRY1 (cryptochrome circadian regulator 1) and CRY2 (cryptochrome circadian regulator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See phr6-4 in Genome Data Viewer
    Location:
    38D2-38D2; 2-54 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20643351..20645791, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20643351..20645791, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Seminal fluid protein 38D Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene U snoRNA host gene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the T(6-4)C lesion in complex with a (6-4) DNA photolyase and repair of UV-induced (6-4) and Dewar photolesions. Glas AF, et al. Chemistry, 2009 Oct 12. PMID 19722240
    2. Characterization of (6-4) photoproduct DNA photolyase. Kim ST, et al. J Biol Chem, 1994 Mar 18. PMID 8132580
    3. A new photoreactivating enzyme that specifically repairs ultraviolet light-induced (6-4)photoproducts. Todo T, et al. Nature, 1993 Jan 28. PMID 8426655
    4. Reaction mechanism of (6-4) photolyase. Zhao X, et al. J Biol Chem, 1997 Dec 19. PMID 9405473
    5. Non-mutagenic repair of (6-4)photoproducts by (6-4)photolyase purified from Drosophila melanogaster. Todo T, et al. Mutat Res, 1997 Nov. PMID 9447230

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Electron Transfer-Induced Active Site Structural Relaxation in 64-Photolyase of Drosophila melanogaster.
      Title: Electron Transfer-Induced Active Site Structural Relaxation in 64-Photolyase of Drosophila melanogaster.
    2. The first crystal structures of a (6-4) photolyase was described.
      Title: Crystal structure and mechanism of a DNA (6-4) photolyase.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables FAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deoxyribodipyrimidine photo-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deoxyribodipyrimidine photo-lyase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in circadian regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in entrainment of circadian clock by photoperiod IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    (6-4)-photolyase
    Names
    (6-4) photolyase
    (6-4)photolyase
    6-4 photolyase
    64-photolyase
    CG2488-PA
    CG2488-PB
    CG2488-PC
    CG2488-PD
    photolyase
    phr6-4-PA
    phr6-4-PB
    phr6-4-PC
    phr6-4-PD
    NP_001260632.1
    NP_001260633.1
    NP_477188.1
    NP_724274.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      20643351..20645791 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165334.3 → NP_724274.1  (6-4)-photolyase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724274.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8P0, Q8SXK5
      Related
      FBpp0080934
      Conserved Domains (2) summary
      COG0415
      Location:5 → 499
      PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
      pfam03441
      Location:297 → 496
      FAD_binding_7; FAD binding domain of DNA photolyase

    2. NM_057840.5 → NP_477188.1  (6-4)-photolyase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477188.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8P0, Q8SXK5
      Related
      FBpp0080935
      Conserved Domains (2) summary
      COG0415
      Location:5 → 499
      PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
      pfam03441
      Location:297 → 496
      FAD_binding_7; FAD binding domain of DNA photolyase

    3. NM_001273704.1 → NP_001260633.1  (6-4)-photolyase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260633.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8P0, Q8SXK5
      Conserved Domains (2) summary
      COG0415
      Location:5 → 499
      PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
      pfam03441
      Location:297 → 496
      FAD_binding_7; FAD binding domain of DNA photolyase

    4. NM_001273703.1 → NP_001260632.1  (6-4)-photolyase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260632.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8P0, Q8SXK5
      Conserved Domains (2) summary
      COG0415
      Location:5 → 499
      PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
      pfam03441
      Location:297 → 496
      FAD_binding_7; FAD binding domain of DNA photolyase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0E8P0 Q0E8P0
    Q24281 Q24281
    Q8SXK5 Q8SXK5

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