Acp65Aa Adult cuticle protein 65Aa [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Acp65Aaprovided by FlyBase
Official Full Name: Adult cuticle protein 65Aaprovided by FlyBase
Primary source: FLYBASE:FBgn0020765
Locus tag: Dmel_CG10297
See related: AllianceGenome:FB:FBgn0020765
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Acp65A; ACP65A; BcDNA:RH61147; CG10297; DCP5; DMACP65A; DmelAcp65Aa; Dmel\CG10297
Summary: Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. Is expressed in adult head; embryonic dorsal epidermis; and embryonic ventral epidermis. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (6152050..6152745, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (6145150..6145845, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Juvenile hormone inhibits adult cuticle formation in Drosophila melanogaster through Kr-h1/Dnmt2-mediated DNA methylation of Acp65A promoter.
Title: Juvenile hormone inhibits adult cuticle formation in Drosophila melanogaster through Kr-h1/Dnmt2-mediated DNA methylation of Acp65A promoter.
The restriction of ACP65A expression appears to depend on a strong repression mechanism.
Title: The cis-regulatory sequences required for expression of the Drosophila melanogaster adult cuticle gene ACP65A.
Broad isoform Z1 suppresses Acp65A expression by preventing the normal up-regulation of DHR38 at the time of adult cuticle formation.
Title: Elucidation of the regulation of an adult cuticle gene Acp65A by the transcription factor Broad.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables structural constituent of chitin-based larval cuticle	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of chitin-based larval cuticle	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in chitin-based cuticle development	ISM Inferred from Sequence Model more info	PubMed

Component	Evidence Code	Pubs
is_active_in chitin-based extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in chitin-based extracellular matrix	ISM Inferred from Sequence Model more info	PubMed