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    qkr54B quaking related 54B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36966, updated on 9-Dec-2024

    Summary

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    Official Symbol
    qkr54Bprovided by FlyBase
    Official Full Name
    quaking related 54Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0022987
    Locus tag
    Dmel_CG4816
    See related
    AllianceGenome:FB:FBgn0022987
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4816; Dmel\CG4816; p62GAP; Qkr54B; QKR54B; qrk54B; Qrk54B; SAM; Sam50; SAM50
    Summary
    Enables RNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Located in cytoplasm. Is expressed in organism and ovary. Orthologous to several human genes including KHDRBS2 (KH RNA binding domain containing, signal transduction associated 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See qkr54B in Genome Data Viewer
    Location:
    54B16-54B16; 2-82 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17469624..17475129)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13357129..13362634)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Testin Neighboring gene insensible Neighboring gene uncharacterized protein Neighboring gene veil

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional and phylogenetic properties of the pore-forming beta-barrel transporters of the Omp85 family. Bredemeier R, et al. J Biol Chem, 2007 Jan 19. PMID 17088246
    2. The identification of two Drosophila K homology domain proteins. Kep1 and SAM are members of the Sam68 family of GSG domain proteins. Di Fruscio M, et al. J Biol Chem, 1998 Nov 13. PMID 9804767
    3. Kep1 interacts genetically with dredd/caspase-8, and kep1 mutants alter the balance of dredd isoforms. Di Fruscio M, et al. Proc Natl Acad Sci U S A, 2003 Feb 18. PMID 12563030, Free PMC Article
    4. A family of Drosophila genes encoding quaking-related maxi-KH domains. Fyrberg C, et al. Biochem Genet, 1998 Feb. PMID 9562906
    5. Insensible is a novel nuclear inhibitor of Notch activity in Drosophila. Coumailleau F, et al. PLoS One, 2014. PMID 24902027, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    quaking related 54B
    Names
    CG4816-PA
    CG4816-PB
    CG4816-PD
    CG4816-PE
    qkr54B-PA
    qkr54B-PB
    qkr54B-PD
    qkr54B-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17469624..17475129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274121.1 → NP_001261050.1  quaking related 54B, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261050.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFT9
      Conserved Domains (2) summary
      cd02395
      Location:122 → 237
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
      pfam16274
      Location:68 → 117
      Qua1; Qua1 domain

    2. NM_166231.3 → NP_725680.2  quaking related 54B, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725680.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAT7, O44433, Q7KNS5
      Conserved Domains (2) summary
      cd02395
      Location:122 → 237
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
      pfam16274
      Location:68 → 117
      Qua1; Qua1 domain

    3. NM_166230.3 → NP_725679.1  quaking related 54B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725679.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAT7, O44433, Q7KNS5
      Related
      FBpp0086079
      Conserved Domains (2) summary
      cd02395
      Location:122 → 237
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
      pfam16274
      Location:68 → 117
      Qua1; Qua1 domain

    4. NM_079048.4 → NP_523772.1  quaking related 54B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523772.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAT7, O44433, Q7KNS5
      Related
      FBpp0086081
      Conserved Domains (2) summary
      cd02395
      Location:122 → 237
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
      pfam16274
      Location:68 → 117
      Qua1; Qua1 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFT9 A0A0B4KFT9
    O44433 O44433
    Q7KNS5 Q7KNS5

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