Tagln transgelin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Taglnprovided by RGD
Official Full Name: transgelinprovided by RGD
Primary source: RGD:3723
See related: EnsemblRapid:ENSRNOG00000017628 AllianceGenome:RGD:3723
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sm22
Summary: Predicted to enable actin filament binding activity and protein-macromolecule adaptor activity. Involved in cellular response to platelet-derived growth factor stimulus. Predicted to be located in cytoplasm. Orthologous to human TAGLN (transgelin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Uterus (RPKM 5700.2), Lung (RPKM 1185.4) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (55121647..55127121, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (46224939..46230413, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (50222895..50228369, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SM22 concentrations were significantly elevated in rats from 4 hours of mesenteric ischemia onwards. Furthermore, SM22 plasma concentrations closely paralleled the histological increasing degree of intestinal smooth muscle damage.
Title: SM22 a Plasma Biomarker for Human Transmural Intestinal Ischemia.
CKII-SIRT1-SM22alpha acts in a loop to reinforce the expression of SM22alpha, which limits the inflammatory response in vascular smooth muscle cells.
Title: CKII-SIRT1-SM22α loop evokes a self-limited inflammatory response in vascular smooth muscle cells.
transgelin is up-regulated in the obstructive nephropathy
Title: Transgelin Up-Regulation in Obstructive Nephropathy.
Enhancements in smooth muscle cell properties such as transgelin expression and actomyosin-mediated contractility/motility might be involved in cell survival after NaHS exposure.
Title: Hydrogen sulfide donor NaHS induces death of alveolar epithelial L2 cells that is associated with cellular shrinkage, transgelin expression and myosin phosphorylation.
SM22alpha is a phosphorylation-regulated suppressor of IKK-IkappaBalpha-NF-kappaB signaling cascades.
Title: SM22α inhibits vascular inflammation via stabilization of IκBα in vascular smooth muscle cells.
TRAF6-SM22alpha-G6PD pathway is a novel mechanism underlying the association between glucose metabolism and VSMC survival, which is beneficial for vascular repair after injury but facilitates atherosclerotic plaque stability.
Title: TRAF6-Mediated SM22α K21 Ubiquitination Promotes G6PD Activation and NADPH Production, Contributing to GSH Homeostasis and VSMC Survival In Vitro and In Vivo.
Speculate that SM22 plays an important role in the regulation of intestinal smooth muscle basal tone via Rho kinase-induced phosphorylation of SM22.
Title: Role of SM22 in the differential regulation of phasic vs. tonic smooth muscle.
Sm22 is present in the cervix of virgin, 11 day, and 20 day pregnant rats.
Title: The persistence of active smooth muscle in the female rat cervix through pregnancy.
Investigated the role of the TGF-beta receptor and its downstream Smad signaling components that regulate SM22-alpha expression in response to SWCNT induction of VAF differentiation into MFs.
Title: Single-walled carbon nanotubes promote rat vascular adventitial fibroblasts to transform into myofibroblasts by SM22-α expression.
Data show that inhibition of SM22alpha phosphorylation abolished the Ang II-activated PKCdelta-p47phox axis and inhibited the hypertrophy and hyperplasia of vascular smooth muscle cells (VSMCs) in vitro and in vivo.
Title: Phosphorylation of smooth muscle 22α facilitates angiotensin II-induced ROS production via activation of the PKCδ-P47phox axis through release of PKCδ and actin dynamics and is associated with hypertrophy and hyperplasia of vascular smooth muscle cells in vitro and in vivo.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142236 (e-PCR)
- UniSTS:19237

RH141059 (e-PCR)
- UniSTS:223059

Tagln (e-PCR), detects polymorphism
- UniSTS:525192

PMC193673P1 (e-PCR)
- UniSTS:271753

MARC_7597-7598:992008547:1 (e-PCR)
- UniSTS:231351

MARC_7597-7598:996687993:1 (e-PCR)
- UniSTS:231351

PMC150745P2 (e-PCR)
- UniSTS:271102

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	TAS Traceable Author Statement more info	PubMed
enables protein-macromolecule adaptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to platelet-derived growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
NOT acts_upstream_of_or_within cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transgelin

Names: SM22-alpha; smooth muscle 22 protein; smooth muscle protein 22-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031549.2 → NP_113737.1 transgelin

See identical proteins and their annotated locations for NP_113737.1

Status: PROVISIONAL

Source sequence(s)

BC061770

UniProtKB/Swiss-Prot

P31232

UniProtKB/TrEMBL

A0A0G2JWK7, A6J463

Related

ENSRNOP00000024030.5, ENSRNOT00000024030.8

Conserved Domains (2) summary

pfam00402
Location:175 → 199

Calponin; Calponin family repeat

cd21279
Location:23 → 143

CH_TAGLN; calponin homology (CH) domain found in transgelin