Atp5f1d ATP synthase F1 subunit delta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atp5f1dprovided by RGD
Official Full Name: ATP synthase F1 subunit deltaprovided by RGD
Primary source: RGD:621372
See related: EnsemblRapid:ENSRNOG00000014625 AllianceGenome:RGD:621372
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Atp5d
Summary: Contributes to ATP hydrolysis activity. Involved in response to resveratrol. Located in mitochondrial inner membrane. Part of proton-transporting ATP synthase complex, catalytic core F(1). Used to study obesity. Biomarker of colitis and myocardial infarction. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 5. Orthologous to human ATP5F1D (ATP synthase F1 subunit delta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 508.9), Muscle (RPKM 355.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (10211260..10218989, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (9560604..9565919, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (12426807..12432120, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH134373 (e-PCR)
- UniSTS:217655

BI275930 (e-PCR)
- UniSTS:249668

D7Got1 (e-PCR)
- UniSTS:111827

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to proton-transporting ATP synthase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info
enables proton-transporting ATP synthase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info
contributes_to proton-transporting ATP synthase activity, rotational mechanism	ISO Inferred from Sequence Orthology more info
enables proton-transporting ATP synthase activity, rotational mechanism	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in aerobic respiration	ISO Inferred from Sequence Orthology more info
involved_in aerobic respiration	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial proton-transporting ATP synthase complex assembly	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial proton-transporting ATP synthase complex assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial proton-transporting ATP synthase complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in proton motive force-driven ATP synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton motive force-driven ATP synthesis	IEA Inferred from Electronic Annotation more info
involved_in proton motive force-driven ATP synthesis	TAS Traceable Author Statement more info	PubMed
involved_in proton motive force-driven mitochondrial ATP synthesis	IEA Inferred from Electronic Annotation more info
involved_in proton motive force-driven mitochondrial ATP synthesis	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in response to resveratrol	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
part_of proton-transporting ATP synthase complex	IDA Inferred from Direct Assay more info	PubMed
part_of proton-transporting ATP synthase complex	ISO Inferred from Sequence Orthology more info
part_of proton-transporting ATP synthase complex	TAS Traceable Author Statement more info	PubMed
part_of proton-transporting ATP synthase complex, catalytic core F(1)	IBA Inferred from Biological aspect of Ancestor more info
part_of proton-transporting ATP synthase complex, catalytic core F(1)	IDA Inferred from Direct Assay more info	PubMed
part_of proton-transporting ATP synthase complex, catalytic core F(1)	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP synthase subunit delta, mitochondrial

Names: ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit; F-ATPase delta subunit

NP_620806.2

EC 3.6.1.14

XP_006240907.1

EC 3.6.1.14

XP_063119057.1

EC 3.6.1.14

XP_063119058.1

EC 3.6.1.14

XP_063119059.1

EC 3.6.1.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139106.2 → NP_620806.2 ATP synthase subunit delta, mitochondrial precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

P35434

UniProtKB/TrEMBL

A6K8Q6

Conserved Domains (1) summary

cd12152
Location:38 → 162

F1-ATPase_delta; mitochondrial ATP synthase delta subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

10211260..10218989 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063262988.1 → XP_063119058.1 ATP synthase subunit delta, mitochondrial isoform X1

UniProtKB/TrEMBL

G3V7Y3
XM_006240845.4 → XP_006240907.1 ATP synthase subunit delta, mitochondrial isoform X1

UniProtKB/TrEMBL

G3V7Y3

Related

ENSRNOP00000020670.2, ENSRNOT00000020670.6

Conserved Domains (2) summary

cd12152
Location:99 → 223

F1-ATPase_delta; mitochondrial ATP synthase delta subunit

COG0355
Location:98 → 228

AtpC; FoF1-type ATP synthase, epsilon subunit [Energy production and conversion]
XM_063262989.1 → XP_063119059.1 ATP synthase subunit delta, mitochondrial isoform X1

UniProtKB/TrEMBL

G3V7Y3
XM_063262987.1 → XP_063119057.1 ATP synthase subunit delta, mitochondrial isoform X1

UniProtKB/TrEMBL

G3V7Y3