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    Cox14 cytochrome c oxidase assembly factor COX14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 681219, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cox14provided by RGD
    Official Full Name
    cytochrome c oxidase assembly factor COX14provided by RGD
    Primary source
    RGD:1598052
    See related
    EnsemblRapid:ENSRNOG00000084326 AllianceGenome:RGD:1598052
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    C12orf62
    Summary
    Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Predicted to be located in mitochondrial outer membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 10. Orthologous to human COX14 (cytochrome c oxidase assembly factor COX14). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 480.8), Heart (RPKM 434.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cox14 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (132731069..132733159)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (130852226..130854316)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (141378537..141380960)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene SWI/SNF related BAF chromatin remodeling complex subunit D1 Neighboring gene glycerol-3-phosphate dehydrogenase 1 Neighboring gene ceramide synthase 5 Neighboring gene uncharacterized LOC134479573 Neighboring gene LIM domain and actin binding 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in C12orf62, a factor that couples COX I synthesis with cytochrome c oxidase assembly, cause fatal neonatal lactic acidosis. Weraarpachai W, et al. Am J Hum Genet, 2012 Jan 13. PMID 22243966, Free PMC Article
    2. Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase. Szklarczyk R, et al. Genome Biol, 2012 Feb 22. PMID 22356826, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105597

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase assembly protein COX14
    Names
    COX14 cytochrome c oxidase assembly
    COX14, cytochrome c oxidase assembly factor
    cytochrome c oxidase assembly protein 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001377081.1 → NP_001364010.1  cytochrome c oxidase assembly protein COX14

      Status: VALIDATED

      Source sequence(s)
      BC084716
      UniProtKB/Swiss-Prot
      Q5XFV8
      Related
      ENSRNOP00000108619.1, ENSRNOT00000149659.1
      Conserved Domains (1) summary
      pfam14880
      Location:1 → 52
      COX14; Cytochrome oxidase c assembly

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      132731069..132733159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XFV8.1 GenPept UniProtKB/Swiss-Prot:Q5XFV8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
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