Camk2b calcium/calmodulin-dependent protein kinase II beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Camk2bprovided by RGD
Official Full Name: calcium/calmodulin-dependent protein kinase II betaprovided by RGD
Primary source: RGD:2262
See related: EnsemblRapid:ENSRNOG00000052080 AllianceGenome:RGD:2262
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ck2b
Summary: Enables calcium/calmodulin-dependent protein kinase activity; phospholipase binding activity; and protein kinase binding activity. A structural constituent of postsynaptic actin cytoskeleton. Involved in several processes, including cellular response to homocysteine; hippocampal neuron apoptotic process; and regulation of synapse organization. Acts upstream of or within long-term synaptic potentiation. Located in dendrite and perikaryon. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 54. Orthologous to human CAMK2B (calcium/calmodulin dependent protein kinase II beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 523.5) and Muscle (RPKM 264.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (85059166..85148121, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (80845206..80934172, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (86208876..86297727, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of Camk2b Overexpression and Underexpression on the Proteome of Rat Hippocampal Neurons.
Title: Effects of Camk2b Overexpression and Underexpression on the Proteome of Rat Hippocampal Neurons.
This study provides the first evidence to show that CaMKIIbeta interacts with drebrin in dendritic spines.
Title: CaMKIIβ is localized in dendritic spines as both drebrin-dependent and drebrin-independent pools.
Significantly upregulated the expression levels of CaMKIIbeta.
Title: Proteomic Profile of Carbonylated Proteins Screen Regulation of Apoptosis via CaMK Signaling in Response to Regular Aerobic Exercise.
these data establish a potential signaling pathway of Ca2+-CaMKII-CREB in neuronal activation.
Title: CaMKII-Mediated CREB Phosphorylation Is Involved in Ca2+-Induced BDNF mRNA Transcription and Neurite Outgrowth Promoted by Electrical Stimulation.
VLDLR requires RasGRF1/CaMKII to alter dendritic spine formation.
Title: Very low density lipoprotein receptor regulates dendritic spine formation in a RasGRF1/CaMKII dependent manner.
Results suggest that a sodium-dependent glutamate transporter-CaMKIIbeta-actin cytoskeleton axis plays an important role in the regulation of oligodendrocyte maturation and central nervous system myelination
Title: Activation of sodium-dependent glutamate transporters regulates the morphological aspects of oligodendrocyte maturation via signaling through calcium/calmodulin-dependent kinase IIβ's actin-binding/-stabilizing domain.
BDNF-induced CaMKIIbeta phosphorylation and premature synapse formation were suppressed in GIT1 (S419A) transfected cortical neurons
Title: G-protein-coupled receptor kinase interactor-1 serine 419 accelerates premature synapse formation in cortical neurons by interacting with Ca(2+)/calmodulin-dependent protein kinase IIβ.
These results identify betaCaMKII as a powerful regulator of lateral habenula neuron function and a key molecular determinant of depression.
Title: βCaMKII in lateral habenula mediates core symptoms of depression.
Study shows targeting of Arc to inactive synapses via a high-affinity interaction with CaMKIIbeta that is not bound to calmodulin.
Title: Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIβ.
Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation.
Title: Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D14Rat93 (e-PCR), detects polymorphism
- UniSTS:226662

BF405463 (e-PCR)
- UniSTS:247914

PMC145549P1 (e-PCR)
- UniSTS:271004

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium/calmodulin-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium/calmodulin-dependent protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium/calmodulin-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables calcium/calmodulin-dependent protein kinase activity	ISO Inferred from Sequence Orthology more info
enables calcium/calmodulin-dependent protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phospholipase binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables structural constituent of postsynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of postsynaptic actin cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within activation of meiosis involved in egg activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to homocysteine	IEP Inferred from Expression Pattern more info	PubMed
involved_in hippocampal neuron apoptotic process	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within inhibitory G protein-coupled receptor phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synapse maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron migration	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuron migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neuronal synaptic plasticity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein localization to plasma membrane	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of synapse maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse maturation	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of synapse maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of synaptic transmission, cholinergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to cadmium ion	ISO Inferred from Sequence Orthology more info
involved_in response to psychosocial stress	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of calcium- and calmodulin-dependent protein kinase complex	IEA Inferred from Electronic Annotation more info
part_of calcium- and calmodulin-dependent protein kinase complex	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in spindle midzone	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calcium/calmodulin-dependent protein kinase type II subunit beta

Names: Ca++/calmodulin-dependent protein kinase II beta subunit; caM kinase II subunit beta; caM-kinase II beta chain; caMK-II subunit beta; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta; calcium/calmodulin-dependent protein kinase type II beta chain

NP_001035813.1

EC 2.7.11.17

NP_001035815.1

EC 2.7.11.17

NP_068507.2

EC 2.7.11.17

XP_006251232.1

EC 2.7.11.17

XP_006251233.1

EC 2.7.11.17

XP_006251234.1

EC 2.7.11.17

XP_006251236.1

EC 2.7.11.17

XP_006251238.1

EC 2.7.11.17

XP_006251239.1

EC 2.7.11.17

XP_017454558.1

EC 2.7.11.17

XP_017454561.1

EC 2.7.11.17

XP_038947544.1

EC 2.7.11.17

XP_063128923.1

EC 2.7.11.17

XP_063128924.1

EC 2.7.11.17

XP_063128925.1

EC 2.7.11.17

XP_063128926.1

EC 2.7.11.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042354.1 → NP_001035813.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 1

See identical proteins and their annotated locations for NP_001035813.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).

Source sequence(s)

CB616255, CO395982, CO406099, JAXUCZ010000014, X83375

UniProtKB/TrEMBL

A6IKR6, F1LNI8, Q63094

Related

ENSRNOP00000068938.2, ENSRNOT00000081607.3

Conserved Domains (3) summary

smart00220
Location:14 → 272

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:457 → 584

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
NM_001042356.1 → NP_001035815.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 3

See identical proteins and their annotated locations for NP_001035815.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two alternate, in-frame exons in the 3' coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.

Source sequence(s)

CB616255, CB692429, CB728582, JAXUCZ010000014, M16112

UniProtKB/Swiss-Prot

P08413

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:371 → 498

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
NM_021739.2 → NP_068507.2 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2

See identical proteins and their annotated locations for NP_068507.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) has multiple differences in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.

Source sequence(s)

CB616255, CO395982, JAXUCZ010000014, M16112

UniProtKB/Swiss-Prot

P08413

UniProtKB/TrEMBL

A6IKR8, G3V9G3

Related

ENSRNOP00000084286.1, ENSRNOT00000116744.2

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:410 → 537

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

85059166..85148121 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017599069.3 → XP_017454558.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X4

UniProtKB/TrEMBL

A0A8I5ZX82
XM_006251174.5 → XP_006251236.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X6

UniProtKB/TrEMBL

A6IKR6, Q63094

Conserved Domains (3) summary

smart00220
Location:14 → 272

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:495 → 622

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_063272856.1 → XP_063128926.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X13
XM_006251172.5 → XP_006251234.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X3

UniProtKB/TrEMBL

A0A8I5ZX82

Conserved Domains (3) summary

smart00220
Location:14 → 272

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:510 → 637

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_063272855.1 → XP_063128925.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X12
XM_006251171.5 → XP_006251233.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X2

UniProtKB/TrEMBL

A0A8I5ZX82

Conserved Domains (3) summary

smart00220
Location:14 → 272

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:519 → 646

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_006251170.5 → XP_006251232.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1

See identical proteins and their annotated locations for XP_006251232.1

UniProtKB/TrEMBL

A0A8I5ZX82, A6IKR9, F1LUE2

Related

ENSRNOP00000058882.2, ENSRNOT00000067162.4

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:534 → 661

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_039091616.2 → XP_038947544.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X11

UniProtKB/Swiss-Prot

P08413

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

cl09109
Location:395 → 496

NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
XM_063272854.1 → XP_063128924.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X7
XM_063272853.1 → XP_063128923.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X5
XM_017599072.3 → XP_017454561.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X10

UniProtKB/Swiss-Prot

P08413

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

cl09109
Location:410 → 511

NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
XM_006251177.5 → XP_006251239.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X9

See identical proteins and their annotated locations for XP_006251239.1

UniProtKB/Swiss-Prot

P08413

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:386 → 513

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_006251176.5 → XP_006251238.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X8

See identical proteins and their annotated locations for XP_006251238.1

UniProtKB/Swiss-Prot

P08413

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:395 → 522

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain