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    Abcd3 ATP binding cassette subfamily D member 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32992, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Abcd3provided by FlyBase
    Official Full Name
    ATP binding cassette subfamily D member 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0031069
    Locus tag
    Dmel_CG12703
    See related
    AllianceGenome:FB:FBgn0031069
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ABCD; ABCD3; CG12703; DmCG12703; Dmel\CG12703; i17; Pmp70; PMP70
    Summary
    Predicted to enable ATP binding activity; ATPase-coupled transmembrane transporter activity; and long-chain fatty acid transmembrane transporter activity. Predicted to be involved in fatty acid catabolic process; long-chain fatty acid import into peroxisome; and peroxisome organization. Predicted to be located in membrane. Predicted to be active in peroxisomal membrane. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in Zellweger syndrome and congenital bile acid synthesis defect 5. Orthologous to human ABCD3 (ATP binding cassette subfamily D member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Abcd3 in Genome Data Viewer
    Location:
    18F1-18F1; 1-64 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19750770..19759280)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19644803..19653313)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45501 Neighboring gene parvin Neighboring gene Augmenter of liver regeneration Neighboring gene uncharacterized protein Neighboring gene zelda Neighboring gene long non-coding RNA:CR44885

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of HSPA9 induces peroxisomal degradation by increasing pexophagy. Jo DS, et al. Autophagy, 2020 Nov. PMID 31964216, Free PMC Article
    2. Drosophila carrying pex3 or pex16 mutations are models of Zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes. Nakayama M, et al. PLoS One, 2011. PMID 21826223, Free PMC Article
    3. Dietary Stimuli, Intestinal Bacteria and Peptide Hormones Regulate Female Drosophila Defecation Rate. Kotronarou K, et al. Metabolites, 2023 Feb 12. PMID 36837883, Free PMC Article
    4. Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity. Bolukbasi E, et al. Cell Rep, 2017 Oct 17. PMID 29045833, Free PMC Article
    5. Sex chromosome-specific regulation in the Drosophila male germline but little evidence for chromosomal dosage compensation or meiotic inactivation. Meiklejohn CD, et al. PLoS Biol, 2011 Aug. PMID 21857805, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid import into peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peroxisome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in very long-chain fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ATP binding cassette subfamily D member 3
    Names
    Abcd3-PA
    Abcd3-PB
    Abcd3-PC
    Abcd3-PD
    CG12703-PA
    CG12703-PB
    CG12703-PC
    CG12703-PD
    Pmp70
    peroxisomal membrane protein 70 kDa
    NP_001259732.1
    NP_001259733.1
    NP_001259734.1
    NP_608354.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19750770..19759280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272805.1 → NP_001259734.1  ATP binding cassette subfamily D member 3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259734.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWC8
      Conserved Domains (3) summary
      cd03223
      Location:446 → 651
      ABCD_peroxisomal_ALDP; ATP-binding cassette domain of peroxisomal transporter, subfamily D
      TIGR00954
      Location:3 → 653
      3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein
      pfam06472
      Location:63 → 342
      ABC_membrane_2; ABC transporter transmembrane region 2

    2. NM_134510.2 → NP_608354.1  ATP binding cassette subfamily D member 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608354.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWC8
      Related
      FBpp0074564
      Conserved Domains (3) summary
      cd03223
      Location:446 → 651
      ABCD_peroxisomal_ALDP; ATP-binding cassette domain of peroxisomal transporter, subfamily D
      TIGR00954
      Location:3 → 653
      3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein
      pfam06472
      Location:63 → 342
      ABC_membrane_2; ABC transporter transmembrane region 2

    3. NM_001272803.1 → NP_001259732.1  ATP binding cassette subfamily D member 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259732.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWC8
      Conserved Domains (3) summary
      cd03223
      Location:446 → 651
      ABCD_peroxisomal_ALDP; ATP-binding cassette domain of peroxisomal transporter, subfamily D
      TIGR00954
      Location:3 → 653
      3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein
      pfam06472
      Location:63 → 342
      ABC_membrane_2; ABC transporter transmembrane region 2

    4. NM_001272804.1 → NP_001259733.1  ATP binding cassette subfamily D member 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259733.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF96
      Conserved Domains (3) summary
      cd03223
      Location:422 → 627
      ABCD_peroxisomal_ALDP; ATP-binding cassette domain of peroxisomal transporter, subfamily D
      TIGR00954
      Location:11 → 629
      3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein
      pfam06472
      Location:39 → 318
      ABC_membrane_2; ABC transporter transmembrane region 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PF96 M9PF96
    Q9VWC8 Q9VWC8

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